Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Aug 10;142(6):500-502.
doi: 10.1182/blood.2023020811.

An AID to follicular lymphoma transformation

James D Phelan  1 , Elaine S Jaffe  1
Affiliations
Editorial

An AID to follicular lymphoma transformation

James D Phelan et al. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Whole genome sequencing identified 2 subtypes of FL with differing risks of histologic transformation. Aberrant somatic hypermutation (aSHM) induced by AID was associated with increased risk of transformation and increased number of mutations shared with GCB DLCBL. This subset was named DLBCL-like FL (dFL). Conversely, the cohort with lower risk of transformation showed less aSHM and fewer overall mutations, and enrichment for missense mutations of CREBBP, ATP6V1BP2, ATP6AP1, and RRAGC. This subset was named constrained FL (cFL).
See this image and copyright information in PMC

Comment on

References

    1. Dreval K, Hilton LK, Cruz M, et al. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023;142(6):561–573. - PubMed
    1. Wright GW, Huang DW, Phelan JD, et al. A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Cancer Cell. 2020;37(4):551–568.e14. - PMC - PubMed
    1. Garcia-Ramirez I, Tadros S, Gonzalez-Herrero I, et al. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice. Blood. 2017;129(19):2645–2656. - PMC - PubMed
    1. Kridel R, Mottok A, Farinha P, et al. Cell of origin of transformed follicular lymphoma. Blood. 2015;126(18):2118–2127. - PMC - PubMed
    1. Crouch S, Painter D, Barrans SL, et al. Molecular subclusters of follicular lymphoma: a report from the United Kingdom's Haematological Malignancy Research Network. Blood Adv. 2022;6(21):5716–5731. - PMC - PubMed

Substances