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. 1986 Sep 26;873(2):290-6.
doi: 10.1016/0167-4838(86)90056-7.

A model of the mechanism of enzyme action in terms of protein conformational relaxation

I S Averbukh, L A Blumenfeld, V A Kovarsky, N F Perelman

A model of the mechanism of enzyme action in terms of protein conformational relaxation

I S Averbukh et al. Biochim Biophys Acta. .

Abstract

A theoretical model of enzymatic reaction is formulated in which the modulation of the reaction coordinates by low-frequency conformational motions of the enzyme molecule causes the lowering of the activation energy barriers until they completely disappear. If the rates of electron transitions in the enzyme-substrate complex exceed the characteristic frequencies of conformational motions then the rate of the elementary enzymatic reaction shows hysteresis dependence on temperature and substrate concentration.

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