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. 2024 Feb 14;229(2):448-456.
doi: 10.1093/infdis/jiad330.

Human Papillomavirus Concordance Between Parents and Their Newborn Offspring: Results From the Finnish Family Human Papillomavirus Study

Nelli T Suominen  1   2 , Tiina H Luukkaala  3   4 , Claudie Laprise  5 , Marjut A Haataja  1 , Seija E Grénman  1 , Stina M Syrjänen  6   7 , Karolina Louvanto  6   8   9
Affiliations

Human Papillomavirus Concordance Between Parents and Their Newborn Offspring: Results From the Finnish Family Human Papillomavirus Study

Nelli T Suominen et al. J Infect Dis. .

Abstract

Background: The knowledge on vertical human papillomavirus (HPV) transmission is limited. We aimed to determine whether HPV transmission from parents to their offspring occurs before or during birth.

Methods: Altogether, 321 mothers, 134 fathers, and their 321 newborn offspring from the Finnish Family HPV study cohort were included. Parents' genital and oral brush samples and semen samples were collected for HPV testing at baseline (36 weeks of pregnancy). Oral, genital, and umbilical samples from the newborn and placenta samples were collected for HPV testing immediately after delivery. HPV risk for the newborn was calculated from the mother's and father's HPV status by using logistic regression analyses.

Results: Concordances between mothers' and their newborns' HPV genotype at any site were statistically significant with HPV-6, -16, -18, -31, and -56; odds ratios (ORs) ranged from 3.41 (95% confidence interval [CI], 1.80-6.48) for HPV-16 to 634 (95% CI, 28.5-14 087) for HPV-31. Father-newborn HPV concordance was statistically significant with HPV-6 and HPV-31 (ORs, 4.89 [95% CI, 1.09-21.9] and 65.0 [95% CI, 2.92-1448], respectively).

Conclusions: The genotype-specific HPV concordance between parents and their newborn is suggestive for vertical HPV transmission. However, transmission from the father to the newborn remains more uncertain.

Keywords: HPV; father; human papillomavirus; perinatal; vertical transmission.

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Conflict of interest statement

Potential conflicts of interest . All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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References

    1. Malagón T, MacCosham A, Burchell AN, et al. . Sex- and type-specific genital human papillomavirus transmission rates between heterosexual partners: a Bayesian reanalysis of the HITCH cohort. Epidemiology 2021; 32:368–77. - PMC - PubMed
    1. Kero K, Rautava J. HPV Infections in heterosexual couples: mechanisms and covariates of virus transmission. Acta Cytol 2019; 63:143–7. - PubMed
    1. Liu Z, Rashid T, Nyitray AG. Penises not required: a systematic review of the potential for human papillomavirus horizontal transmission that is non-sexual or does not include penile penetration. Sex Health 2016; 13:10–21. - PubMed
    1. Merckx M, Liesbeth WVW, Arbyn M, et al. . Transmission of carcinogenic human papillomavirus types from mother to child: a meta-analysis of published studies. Eur J Cancer Prev 2013; 22:277–85. - PubMed
    1. Palma S, Gnambs T, Crevenna R, Jordakieva G. Airborne human papillomavirus (HPV) transmission risk during ablation procedures: a systematic review and meta-analysis. Environ Res 2021; 192:110437. - PubMed

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