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. 2023 Aug 11;21(1):245.
doi: 10.1186/s12957-023-03137-z.

The value of lymph nodes ratios in the prognosis of resectable remnant gastric cancer through the retrospective propensity score matching analysis

Biao Yang #  1 , Tao Liu #  2 , Hangtian Cui  1 , Zhengmao Lu  1 , Guoen Fang  1 , Xuchao Xue  1 , Tianhang Luo  3
Affiliations

The value of lymph nodes ratios in the prognosis of resectable remnant gastric cancer through the retrospective propensity score matching analysis

Biao Yang et al. World J Surg Oncol. .

Abstract

Purpose: Currently, the characteristics and prognosis of remnant gastric cancer (RGC) are not fully understood yet. The present study aimed to describe the details of clinicopathological features of resectable RGC and investigated the factors affecting survival after the curative operation.

Methods: From Jan. 2006 to Dec. 2015, a total of 118 resectable RGC patients (the RGC group) and 236 age-, sex- and TNM stages-matched resectable gastric cancer (GC) patients (the control group) were recruited retrospectively. Clinicopathological characteristics and overall survival were compared between the two groups.

Results: The overall survival rate was 46.61% for RGC patients compared to 55.08% for control groups (P < 0.01), and the mean overall survival time of RGC patients was 40.23 ± 32.27 months, compared to 55.06 ± 34.29 months in the control group (P = 0.023 after matching). The overall survival (OS) of RGC patients with stage IIb was much worse than IIa (P < 0.001) and similar to IIIa (P = 0.463) and IIIb (P = 0.014). Multivariate Cox proportional hazards model analysis revealed that TNM stage (HR: 3.899, P < 0.001) and lymph nodes ratio (LNR) (HR: 2.405, P = 0.028) were independent prognostic significance to OS.

Conclusions: The OS of RGC was much worse than GC with similar TNM stages, and LNR might consider a highly reliable indicator to evaluate the prognostic in RGC.

Keywords: Clinicopathological characteristics; Lymph nodes ratio; Overall survival; Remnant gastric cancer.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the selection of study participants
Fig. 2
Fig. 2
The OS curves of RGC and GC. A The OS curves of RGC and GC before matching. B Overall survival curves of RGC and GC after matching. RGC, remnant gastric cancer; GC, gastric cancer; OS, overall survival
Fig. 3
Fig. 3
The OS curves of RGC and GC are stratified by the TNM stage. A, B The OS of RGC with stage I was similar to GC (p = 0.227; 0.078). C-E The OS of RGC with stage III was similar to GC (p = 0.174; 0.212; 0.538). F, G The OS of RGC with stage II was worse than GC (p = 0.064; 0.023). RGC, remnant gastric cancer; GC, gastric cancer; OS, overall survival; TNM, tumor node metastasis
Fig. 4
Fig. 4
The OS curves of RGC with stage IIb. A The OS of RGC with stage IIb was similar to GC with stage IIIa (p = 0.736). B The OS of RGC with stage IIb was similar to GC with stage IIIb (p = 0.105). RGC, remnant gastric cancer; GC, gastric cancer; OS, overall survival
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