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Case Reports
. 2023 Jul 10;15(7):e41633.
doi: 10.7759/cureus.41633. eCollection 2023 Jul.

Eosinophilic Variant of Granulomatosis With Polyangiitis

Rui L Fernandes  1 , Mariana F Ornelas  2 , Ana C Henriques  1 , Maria I Correia  1 , Teresa Faria  1
Affiliations
Case Reports

Eosinophilic Variant of Granulomatosis With Polyangiitis

Rui L Fernandes et al. Cureus. .

Abstract

Granulomatosis with polyangiitis (GPA) is a multisystemic necrotizing vasculitis with a special tropism to the respiratory tract and the kidneys. Although uncommon, GPA may be associated with hypereosinophilia and limited organ involvement. In these cases, American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria may be insufficient to establish the diagnosis. We described a limited form of GPA, hypereosinophilia, and predominant skin involvement.

Keywords: autoimmune-associated vasculitis; eosinophilic granulomatosis with polyangiitis; erythroderma; granulomatosis with polyangiitis; hypereosinophilia.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. At physical examination, skin involvement was predominant. The skin was flushed, thick, and itchy.
Figure 2
Figure 2. Chest CT. Red arrows show some of the granulomas. CT scan reassessment after beginning steroids did not show modifications.
Figure 3
Figure 3. The 2022 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria to GPA and EGPA. A score ≥ 6 is needed for classification of EGPA and ≥ 5 for GPA.
ANCA: Anti-neutrophil cytoplasmic antibody
See this image and copyright information in PMC

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