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. 2023 Aug;95(8):e28989.
doi: 10.1002/jmv.28989.

Ancestral SARS-CoV-2 and Omicron BA.5-specific neutralizing antibody and T-cell responses after Omicron bivalent booster vaccination in previously infected and infection-naive individuals

Willem A Mak  1 , Wendy Visser  1 , Marijke van der Vliet  1 , Hilde Y Markus  1 , Johannes G M Koeleman  1 , David S Y Ong  1   2
Affiliations

Ancestral SARS-CoV-2 and Omicron BA.5-specific neutralizing antibody and T-cell responses after Omicron bivalent booster vaccination in previously infected and infection-naive individuals

Willem A Mak et al. J Med Virol. 2023 Aug.

Abstract

Coronavirus disease-2019 (COVID-19) bivalent ancestral/Omicron messenger RNA (mRNA) booster vaccinations became available to boost and expand the immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infections. In a prospective cohort study including 59 healthcare workers, we assessed SARS-CoV-2 ancestral and Omicron BA.5-specific neutralizing antibody and T-cell responses in previously infected and infection-naive individuals. Also, we assessed the effect of an ancestral/Omicron BA.1 bivalent mRNA booster vaccination on these immune responses. 10 months after previous monovalent mRNA vaccinations, ancestral SARS-CoV-2 S1-specific T-cell and anti-RBD IgG responses remained detectable in most individuals and a previous SARS-CoV-2 infection was associated with increased T-cell responses. T-cell responses, anti-RBD IgG, and Omicron BA.5 neutralization activity increased after receiving an ancestral/Omicron BA.1 bivalent booster mRNA vaccination. An Omicron BA.5 infection in addition to bivalent vaccination, led to a higher ratio of Omicron BA.5 to ancestral strain neutralization activity compared to no bivalent vaccination and no recent SARS-CoV-2 infection. In conclusion, SARS-CoV-2 T-cell and antibody responses persist for up to 10 months after a monovalent booster mRNA vaccination. An ancestral/Omicron BA.1 bivalent booster mRNA vaccination increases these immune responses and also induces Omicron BA.5 cross-neutralization antibody activity. Finally, our data indicate that hybrid immunity is associated with improved preservation of T-cell immunity.

Keywords: COVID-19; Omicron; SARS-CoV-2; T-cells; antibodies; vaccination.

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References

REFERENCES

    1. Xia S, Wang L, Zhu Y, Lu L, Jiang S. Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages. Signal Transduct Target Ther. 2022;7:241. doi:10.1038/s41392-022-01105-9
    1. World Health Organization. COVID-19 Weekly Epidemiological Update 135. 2023.
    1. Doll MK, Waghmare A, Heit A, et al. Acute and postacute COVID-19 outcomes among immunologically naive adults during delta vs omicron waves. JAMA Netwk Open. 2023;6(2):e231181. doi:10.1001/jamanetworkopen.2023.1181
    1. Looi MK. How are covid-19 symptoms changing? BMJ. 2023;380:3. doi:10.1136/bmj.p3
    1. Bahremand T, Yao JA, Mill C, Piszczek J, Grant JM, Smolina K. COVID-19 hospitalisations in immunocompromised individuals in the Omicron era: a population-based observational study using surveillance data in British Columbia, Canada. Lancet Regional Health - Am. 2023;20:100461. doi:10.1016/j.lana.2023.100461

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