Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan;34(1):60-68.
doi: 10.1007/s00330-023-10036-0. Epub 2023 Aug 11.

Spectral CT assists differentiation of osteoblastic bone metastasis from bone island in newly diagnosed cancer patients

Honghong Luo #  1 , Liyan Zou #  1 , Qian Yang  1 , Cuiyun Yuan  2 , Kun Ma  3 , Shangpo Yang  1 , Dehong Luo  1 , Chenbin Liu  4 , Zhou Liu  5
Affiliations

Spectral CT assists differentiation of osteoblastic bone metastasis from bone island in newly diagnosed cancer patients

Honghong Luo et al. Eur Radiol. 2024 Jan.

Abstract

Objectives: To investigate measurements derived from plain and enhanced spectral CT in differentiating osteoblastic bone metastasis (OBM) from bone island (BI).

Materials and methods: From January to November 2020, 73 newly diagnosed cancer patients with 201 bone lesions (OBM = 92, BI = 109) having received spectral CT were retrospectively enrolled. Measurements including CT values of 40-140 keV, slope of the spectral curve, effective atomic number (Zeff), water (calcium) density, calcium (water) density, and Iodine (calcium) density were derived from manually segmented lesions on plain and enhanced spectral CT, and then analyzed using Student t-test and Pearson's correlation. Multivariate analysis was performed to build models (plain spectral model, enhanced spectral CT model, and combined model) for the discrimination of OBM and BI with performance evaluated using receiver operator characteristics curve and DeLong test.

Results: All features were significantly different between the BI group and OBM group (all p < 0.05), highly correlated with the corresponding features between plain and enhanced spectral CT both in OBM (r: 0.392-0.763) and BI (r: 0.430-0.544). As for the model performance, the combined model achieved the best performance (AUC = 0.925, 95% CI: 0.879 to 0.957), which significantly outperformed the plain spectral CT model (AUC = 0.815, 95% CI: 0.754 to 0.866, p < 0.001) and enhanced spectral CT model (AUC = 0.901, 95% CI: 0.852 to 0.939, p = 0.024) in differentiating OBM and BI.

Conclusion: In addition to plain spectral CT measurements, enhanced spectral CT measurements would further significantly benefit the differential diagnosis.

Clinical relevance statement: Measurements derived either from plain or enhanced spectral CT could provide additional valuable information to improve the differential diagnosis between OBM and BI in newly diagnosed cancer patients.

Key points: • We intend to investigate plain and enhanced spectral CT measurements in differentiating OBM from BI. • Both plain and enhanced spectral CT help in discriminating OBM and BI in newly diagnosed cancer patients. • Enhanced spectral CT measurements further improve plain spectral CT measurements-based differential diagnosis.

Keywords: Bone metastasis; Computed tomography; Dual energy; Osteoblastic.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ryan C, Stoltzfus KC, Horn S et al (2020) Epidemiology of bone metastases. Bone 158:115783
    1. Huang JF, Shen J, Li X et al (2020) Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study. Ann Transl Med 8:482 - DOI - PubMed - PMC
    1. Syed AZ, Yannam SD, Pavani G (2017) Research: Prevalence of Dense Bone Island. Compend Contin Educ Dent 38:e13–e16 - PubMed
    1. Caballes RL, Caballes RA Jr (2004) Polyostotic giant enostoses with strongly positive radionuclide bone scan. Ann Diagn Pathol 8:247–251 - DOI - PubMed
    1. Onitsuka H (1977) Roentgenologic aspects of bone islands. Radiology 123:607–612 - DOI - PubMed

LinkOut - more resources