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. 2023 Oct;40(10):2385-2390.
doi: 10.1007/s10815-023-02905-w. Epub 2023 Aug 11.

Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex

C E Dunlop  1 , S A Jack  2 , E E Telfer  3 , S Zahra  4 , R A Anderson  2   5
Affiliations

Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex

C E Dunlop et al. J Assist Reprod Genet. 2023 Oct.

Abstract

Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biological family to selected patients with TS. To date, women with TS have had ovarian tissue cryopreserved but there are few reports of autologous re-implantation and none of pregnancy. We herein report, to our knowledge, the first clinical pregnancy in a patient with TS, conceived naturally following re-implantation of cryopreserved ovarian tissue which had been removed soon after spontaneous puberty. This provides proof of concept for OTC as a means of fertility preservation in TS.

Keywords: Fertility preservation; Ovarian cortex re-implantation; Premature ovarian insufficiency; Turner syndrome.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Image from the laparoscopic ovarian cortex biopsy procedure demonstrating a normal uterus, normal right Fallopian tube and small right ovary
Fig. 2
Fig. 2
Histological image of a biopsy of ovarian cortex removed during ovarian cortex cryopreservation procedure demonstrating a single primordial follicle, surrounded by normal ovarian stroma
See this image and copyright information in PMC

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