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Comment
. 2023 Dec;33(12):898-899.
doi: 10.1038/s41422-023-00860-w.

Uridine: as sweet as sugar for some cells?

Matthew H Ward  1   2 , Zeribe C Nwosu  3 , Costas A Lyssiotis  4   5   6
Affiliations
Comment

Uridine: as sweet as sugar for some cells?

Matthew H Ward et al. Cell Res. 2023 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1. Uridine fuels dynamically-regulated cancer cell metabolism.
Uridine from several potential sources enters cancer cells, enabling continued tumor growth. Uridine sources include diverse cell types and RNA (based on published evidence), and could include other tumor cells (represented by “CAFs”). Other nucleosides (e.g., inosine, adenosine) may fuel tumors similarly, if available. Exogenous 13C5(ribose)-uridine labeled carbon was traced using liquid chromatography mass spectrometry into the pentose phosphate pathway, central carbon metabolism, amino acid anabolism, glycosylation precursors, redox metabolites, and nucleotides; however, the fate and role of uracil after release by UPP1 is uncertain. UPP1 was regulated transcriptionally by major signaling mechanisms, but the integration of these signals with the unknown nutrient sensing axis remains unstudied. Finally, PGM2 (immediately downstream of UPP1) may also be important for tumor growth. Gray-highlighted question marks indicate areas needing further study. Red crossed lines indicate inhibition; green arrows indicate activation (transcriptionally). CAF cancer-associated fibroblast, GA3P glyceraldehyde 3-phosphate, PDA pancreatic ductal adenocarcinoma, PGM2 phosphoglucomutase-2, PRPP phosphoribosyl pyrophosphate, TAM tumor-associated macrophage, TME tumor microenvironment.
See this image and copyright information in PMC

Comment on

  • Uridine-derived ribose fuels glucose-restricted pancreatic cancer.
    Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee HJ, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. Nwosu ZC, et al. Nature. 2023 Jun;618(7963):151-158. doi: 10.1038/s41586-023-06073-w. Epub 2023 May 17. Nature. 2023. PMID: 37198494 Free PMC article.

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