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. 2023 Aug 11;22(1):130.
doi: 10.1186/s12944-023-01861-9.

Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017-2020

Chun-Feng Lu #  1 , Xiao-Min Cang #  1 , Wang-Shu Liu #  1 , Li-Hua Wang  2 , Hai-Yan Huang  1 , Sheng-Mei Sang  2 , Xue-Qin Wang  3 , Xing-Xing Fang  4 , Feng Xu  5
Affiliations

Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017-2020

Chun-Feng Lu et al. Lipids Health Dis. .

Abstract

The platelet/high-density lipoprotein cholesterol ratio (PHR) is a novel inflammatory and hypercoagulability marker that represents the severity of metabolic syndrome. Liver metabolic syndrome is manifested by nonalcoholic fatty liver disease (NAFLD), which is associated with inflammation and hypercoagulability. This cross-sectional investigation aimed to identify the relationship between PHR and NAFLD. Participants in the National Health and Nutrition Examination Survey (NHANES) 2017-2020 were evaluated for hepatic steatosis and fibrosis using vibration-controlled transient elastography. The PHR was calculated as the ratio of platelets to high-density lipoprotein cholesterol. Increased PHR was associated with an increased incidence of NAFLD and hepatic fibrosis. Compared with patients in the first PHR quartile, after adjustment for clinical variables, the corresponding odds ratio (OR) for NAFLD in the fourth quartile was 2.36 (95% CI, 1.76 to 3.18) (p < 0.05); however, the OR for hepatic fibrosis was not statistically significant (p > 0.05). Furthermore, restricted cubic spline analyses showed an S-shaped association between PHR and NAFLD and an L-shaped relationship between PHR and hepatic fibrosis. The results support the effectiveness of PHR as a marker for NAFLD and hepatic fibrosis. Therefore, interventions to improve the PHR may be of benefit in reducing the incidence of both hepatic steatosis and fibrosis.

Keywords: Hepatic fibrosis; Hypercoagulability; Inflammation; Nonalcoholic fatty liver disease; Platelet/high-density lipoprotein cholesterol ratio.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The nonlinear relationship between the PHR and the risk of NAFLD. A nonlinear relationship was detected after adjusting for sex, education level, age, household income, ethnicity, smoking status, diabetes and hypertension history, HbA1c, TG, TC, and LDL-C
Fig. 2
Fig. 2
The nonlinear relationship between the PHR and the risk of liver fibrosis. A nonlinear relationship was detected after adjusting for sex, education level, age, household income, ethnicity, smoking status, diabetes and hypertension history, HbA1c, TG, TC, and LDL-C
See this image and copyright information in PMC

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