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. 2023 Jul 30;12(15):5020.
doi: 10.3390/jcm12155020.

Changes in Antibiotic Resistance of Acinetobacter baumannii and Pseudomonas aeruginosa Clinical Isolates in a Multi-Profile Hospital in Years 2017-2022 in Wroclaw, Poland

Beata Mączyńska  1 , Agnieszka Jama-Kmiecik  2 , Jolanta Sarowska  2 , Krystyna Woronowicz  3 , Irena Choroszy-Król  2 , Daniel Piątek  4 , Magdalena Frej-Mądrzak  2
Affiliations

Changes in Antibiotic Resistance of Acinetobacter baumannii and Pseudomonas aeruginosa Clinical Isolates in a Multi-Profile Hospital in Years 2017-2022 in Wroclaw, Poland

Beata Mączyńska et al. J Clin Med. .

Abstract

In recent years, we have witnessed increasing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobials, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative Pseudomonas aeruginosa and Acinetobacter baumannii, isolated from infections in a multi-profile hospital over a five-year period (from 2017 to 2022). Among the practical results of the evaluation of these data will be the possibility to determine changes in susceptibility to the antibiotics used in the hospital. This, in turn, will help propose new therapeutic options, especially for empirical therapy, which is essential in severe infections. Analysis of the use of different antibiotic groups has made it possible to identify the causes of increasing resistance in the analyzed Gram-negative bacilli. The highest antibiotic use was observed in the hospital between 2020 and 2022, most probably due to the COVID-19 pandemic and the higher number of patients in severe condition requiring hospitalization. Unfortunately, during the period analyzed, the number of multi-resistant strains of A. baumannii was successively increasing; this seems to be related to the increased use, especially during the pandemic period, of broad-spectrum antibiotics, mainly penicillins with inhibitors, third-generation cephalosporins and carbapenems.

Keywords: carbapenems; multidrug resistance strains; non-fermenting bacilli.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of the number of P. aeruginosa and A. baumannii strains isolated from infections between 2017 and 2022.
Figure 2
Figure 2
Percentage of P. aeruginosa strains resistant to cephalosporins and piperacillin with tazobactam.
Figure 3
Figure 3
Percentage of P. aeruginosa strains resistant to carbapenems.
Figure 4
Figure 4
Comparison of the percentage of P. aeruginosa strains sensitive and resistant to carbapenems and strains producing MBL (+) carbapenemases in 2021 and 2022.
Figure 5
Figure 5
Percentage of P. aeruginosa strains resistant to aminoglycosides.
Figure 6
Figure 6
Percentage of P. aeruginosa strains resistant to quinolones.
Figure 7
Figure 7
Percentage of A. baumannii strains resistant to carbapenems between 2017 and 2022.
Figure 8
Figure 8
Percentage of A. baumannii strains resistant to aminoglycosides in 2017–2022.
Figure 9
Figure 9
Percentage of A. baumannii strains resistant to quinolones in 2017–2022.
See this image and copyright information in PMC

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