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. 2023 Jul 28;15(15):3844.
doi: 10.3390/cancers15153844.

Selective Removal of Only Clinically Suspicious Positive Lymph Nodes Instead of a Complete Inguino-Femoral Lymph Node Dissection in Squamous Cell Carcinoma of the Vulva

Guus Fons  1 , Nikki B Thuijs  2 , Ming Tjiong  1 , Lukas J A Stalpers  3 , Jacobus van der Velden  1
Affiliations

Selective Removal of Only Clinically Suspicious Positive Lymph Nodes Instead of a Complete Inguino-Femoral Lymph Node Dissection in Squamous Cell Carcinoma of the Vulva

Guus Fons et al. Cancers (Basel). .

Abstract

Background: The oncological safety of only removing bulky, positive groin lymph nodes followed by radiotherapy without performing a complete inguino-femoral node dissection (IFL) in squamous cell cancer of the vulva is based on two small studies. The aim of this study was to confirm the oncological safety of this treatment policy.

Methods: The survival of consecutive patients with clinically suspicious and pathologically positive groin nodes treated with the selective removal of these nodes followed by radiotherapy was compared with the survival in historical controls matched for the variables extranodal spread and diameter of the metastasis > 15 mm and treated with a complete IFL.

Results: There was no difference in disease-specific survival between patients treated with debulking (n = 40) versus complete IFL (n = 37) (43.1% vs. 44.8%, p = 0.336, respectively). Overall, survival and groin recurrence-free survival did not differ between the groups either.

Conclusion: This retrospective study in a cohort of women with vulvar cancer corroborates previous smaller studies that have shown that the selective removal of suspicious inguinal nodes yields similar oncological outcomes compared with patients matched for important prognostic variables and treated with a complete IFL when both are followed by radiotherapy.

Keywords: bulky lymph nodes; lymph node debulking; vulvar cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of disease-specific survival of patients who were treated with nodal bulking compared with matched controls (matched for extracapsular spread and size of the metastasis in the node) who were treated with an inguino-femoral lymph node dissection.
See this image and copyright information in PMC

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