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Review
. 2023 Jul 25;28(15):5623.
doi: 10.3390/molecules28155623.

Phytochemical Properties, Extraction, and Pharmacological Benefits of Naringin: A Review

V S Shilpa  1 , Rafeeya Shams  1 , Kshirod Kumar Dash  2 , Vinay Kumar Pandey  3   4 , Aamir Hussain Dar  5 , Shaikh Ayaz Mukarram  6 , Endre Harsányi  7 , Béla Kovács  6
Affiliations
Review

Phytochemical Properties, Extraction, and Pharmacological Benefits of Naringin: A Review

V S Shilpa et al. Molecules. .

Abstract

This review describes the various innovative approaches implemented for naringin extraction as well as the recent developments in the field. Naringin was assessed in terms of its structure, chemical composition, and potential food sources. How naringin works pharmacologically was discussed, including its potential as an anti-diabetic, anti-inflammatory, and hepatoprotective substance. Citrus flavonoids are crucial herbal additives that have a huge spectrum of organic activities. Naringin is a nutritional flavanone glycoside that has been shown to be effective in the treatment of a few chronic disorders associated with ageing. Citrus fruits contain a common flavone glycoside that has specific pharmacological and biological properties. Naringin, a flavone glycoside with a range of intriguing characteristics, is abundant in citrus fruits. Naringin has been shown to have a variety of biological, medicinal, and pharmacological effects. Naringin is hydrolyzed into rhamnose and prunin by the naringinase, which also possesses l-rhamnosidase activity. D-glucosidase subsequently catalyzes the hydrolysis of prunin into glucose and naringenin. Naringin is known for having anti-inflammatory, antioxidant, and tumor-fighting effects. Numerous test animals and cell lines have been used to correlate naringin exposure to asthma, hyperlipidemia, diabetes, cancer, hyperthyroidism, and osteoporosis. This study focused on the many documented actions of naringin in in-vitro and in-vivo experimental and preclinical investigations, as well as its prospective therapeutic advantages, utilizing the information that is presently accessible in the literature. In addition to its pharmacokinetic characteristics, naringin's structure, distribution, different extraction methods, and potential use in the cosmetic, food, pharmaceutical, and animal feed sectors were discussed.

Keywords: bioactive potential; extraction; flavonoid; naringin; pharmaceutical.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular structure of naringin.
Figure 2
Figure 2
The distribution of naringin in Citrus aurantiifolia.
Figure 3
Figure 3
Extraction of naringin using different techniques.
Figure 4
Figure 4
Potential health benefits of naringin; SOD: superoxide dismutase, ROS: Reactive oxygen species, GSH: γ-l-glutamyl-l-cysteinyl-glycine (glutathione).
See this image and copyright information in PMC

References

    1. Alam M.A., Subhan N., Rahman M.M., Uddin S.J., Reza H.M., Sarker S.D. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv. Nutr. 2014;5:404–417. doi: 10.3945/an.113.005603. - DOI - PMC - PubMed
    1. Jakab J., Miškić B., Mikšić Š., Juranić B., Ćosić V., Schwarz D., Včev A. Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products. Diabetes Metab. Syndr. Obes. 2021;14:67–83. doi: 10.2147/DMSO.S281186. - DOI - PMC - PubMed
    1. Su W., Wang Y., Li P., Wu H., Zeng X., Shi R., Zheng Y., Li P., Peng W. The potential application of the traditional Chinese herb Exocarpium Citri grandis in the prevention and treatment of COVID-19. Tradit. Med. Res. 2020;5:160–166. doi: 10.53388/TMR20200406172. - DOI
    1. Tang D.M., Zhu C.F., Zhong S.A., Da Zhou M. Extraction of naringin from pomelo peels as dihydrochalcone’s precursor. J. Sep. Sci. 2011;34:113–117. doi: 10.1002/jssc.201000475. - DOI - PubMed
    1. Ahmed O.M., Mahmoud A.M., Abdel-Moneim A., Ashour M.B. Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. Diabetol. Croat. 2012;41:53–67.

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