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Review
. 2023 Aug 3;28(15):5867.
doi: 10.3390/molecules28155867.

Suppression of Inflamm-Aging by Moringa oleifera and Zingiber officinale Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence

Nur Fatin Nabilah Mohd Sahardi  1 , Suzana Makpol  1
Affiliations
Review

Suppression of Inflamm-Aging by Moringa oleifera and Zingiber officinale Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence

Nur Fatin Nabilah Mohd Sahardi et al. Molecules. .

Abstract

Inflammation or inflamm-aging is a chronic low-grade inflammation that contributes to numerous types of degenerative diseases among the elderly and might be impeded by introducing an anti-inflammatory agent like Moringa oleifera Lam (moringa) and Zingiber officinale Roscoe (ginger). Therefore, this paper aims to review the role of moringa and ginger in suppressing inflamm-aging to prevent degenerative diseases. Various peer-reviewed publications were searched and downloaded using the reputed search engine "Pubmed" and "Google Scholar". These materials were reviewed and tabulated. A comparison between these previous findings was made based on the mechanism of action of moringa and ginger against degenerative diseases, focusing on their anti-inflammatory properties. Many studies have reported the efficacy of moringa and ginger in type 2 diabetes mellitus, neurodegenerative disease, cardiovascular disease, cancer, and kidney disease by reducing inflammatory cytokines activities, mainly of TNF-α and IL-6. They also enhanced the activity of antioxidant enzymes, including catalase, glutathione, and superoxide dismutase. The anti-inflammatory activities can be seen by inhibiting NF-κβ activity. Thus, the anti-inflammatory potential of moringa and ginger in various types of degenerative diseases due to inflamm-aging has been shown in many recent types of research.

Keywords: Moringa oleifera Lam; anti-inflammatory agents; degenerative disease; inflamm-aging and Zingiber officinale Roscoe.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of inflammation. Adapted from [17,18,19,20].
Figure 2
Figure 2
Chemical structures of bioactive components of Moringa oleifera: (A) beta carotene, (B) quercetin, (C) phytol, (D) myricetin, and (E) moringine.
Figure 3
Figure 3
Chemical structures of bioactive components of ginger extract: (A) 6-gingerol, (B) 6-shogaol, (C) zingerone, (D) quercetin, and (E) 8-gingerol.
Figure 4
Figure 4
Mechanism of moringa and ginger in preventing inflammation. Adapted from [38,42].
See this image and copyright information in PMC

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