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Review
. 2023 Aug 4;28(15):5883.
doi: 10.3390/molecules28155883.

The Role and Mechanism of Perilla frutescens in Cancer Treatment

Shicong Huang  1 , Yi Nan  1   2 , Guoqing Chen  1 , Na Ning  1 , Yuhua Du  1 , Doudou Lu  3 , Yating Yang  4 , Fandi Meng  4 , Ling Yuan  1
Affiliations
Review

The Role and Mechanism of Perilla frutescens in Cancer Treatment

Shicong Huang et al. Molecules. .

Abstract

Perilla frutescens is an annual herb of the Labiatae family and is widely grown in several countries in Asia. Perilla frutescens is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that Perilla frutescens has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of Perilla frutescens for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of Perilla frutescens for cancer treatment. It was found that the main active components of Perilla frutescens producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of Perilla frutescens are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to Perilla frutescens.

Keywords: Perilla frutescens; active ingredient; mechanism; tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart. The antitumor effect of Perilla frutescens was verified by web pharmacology analysis of Perilla frutescens. Literature search, review, and synthesis of the literature to summarize the mechanism of action and related signaling pathways of Perilla frutescens as well as active ingredients against tumors. In the red box are cancer-related pathways in the KEGG pathway.
Figure 2
Figure 2
Perilla-active composition target plot and GO and KEGG analyses. In the red box are the signaling pathways associated with various types of cancer in the KEGG enrichment analysis.
Figure 3
Figure 3
The chemical classes of Perilla frutescens compounds.
Figure 4
Figure 4
Structural formulae of representative compounds: (A) Perillaldehyde, (B) Rosmaric acid, (C) Luteolin, and (D) Isoegomaketone.
Figure 5
Figure 5
Anticancer mechanism of Perilla frutescens.
See this image and copyright information in PMC

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