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Review
. 2023 Aug 5;28(15):5901.
doi: 10.3390/molecules28155901.

Phytochemistry and Biological Activities of Murraya Species

Ricky Yohanes  1 , Desi Harneti  1 , Unang Supratman  1   2 , Sofa Fajriah  3 , Tarso Rudiana  4
Affiliations
Review

Phytochemistry and Biological Activities of Murraya Species

Ricky Yohanes et al. Molecules. .

Abstract

Murraya is a plant genus within the Rutaceae family comprising over 17 species, which are widely distributed in Asia, Australia, and the Pacific Islands. Furthermore, these species have been used in traditional medicine to treat fever, pain, and dysentery. Several reports have also extensively studied the leaves, seeds, stembark, and bark of Murraya from 1965 to 2023 to explore their natural product composition. Various phytochemical studies have revealed the isolation of 413 compounds recorded, comprising coumarins, terpenoids, flavonoids, and aromatics, as well as alkaloids, which constitute the largest proportion (46.9%). These isolated compounds have long been known to exhibit different bioactivities, such as cytotoxic and anti-inflammatory properties. Cytotoxic activity has been observed against HCT 116, HeLa, HepG2, and other cell lines. Previous studies have also reported the presence of antifungal, hepatoprotective, antihyperlipidemic, antidiarrheal, and antioxidant effects. Therefore, this review provides a comprehensive overview of Murraya species, highlighting their phytochemistry, biological activities, and potential as a source of active natural compounds.

Keywords: Murraya; Rutaceae; phytochemistry; secondary metabolites.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flow diagram for the systematic review.
Figure 2
Figure 2
Murraya genus. (a) The flower and leaves of M. paniculata [15]. (b) The flowers and leaves of M. koenigii [16].
Figure 3
Figure 3
Distribution of compound groups from the Murraya genus.
Figure 4
Figure 4
Structures of alkaloids from the Murraya genus 1–70.
Figure 5
Figure 5
Structures of alkaloids from the Murraya genus 71–193.
Figure 5
Figure 5
Structures of alkaloids from the Murraya genus 71–193.
Figure 5
Figure 5
Structures of alkaloids from the Murraya genus 71–193.
Figure 6
Figure 6
Structures of coumarins from the Murraya genus 194–314.
Figure 6
Figure 6
Structures of coumarins from the Murraya genus 194–314.
Figure 7
Figure 7
Structures of flavonoids from the Murraya genus 315–362.
Figure 7
Figure 7
Structures of flavonoids from the Murraya genus 315–362.
Figure 8
Figure 8
Structures of terpenoids and steroids from the Murraya genus 363–370.
Figure 9
Figure 9
Structures of other compounds from the Murraya genus 371–413.
Figure 9
Figure 9
Structures of other compounds from the Murraya genus 371–413.
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References

    1. Wilson A. Flora of Australia Volume 26 Meliaceae, Rutaceae, Zygophyllaceae. ABRS Canberra/CSIRO Publishing; Melbourne, Australia: 2013. pp. 501–503.
    1. Ma X.L., Zhu S.S., Liu Y., Chen H.W., Shi Y.T., Zeng K.W., Tu P.F. Carbazole alkaloids with potential cytotoxic activities targeted on PCK2 protein from Murraya microphylla. Bioorganic Chem. 2021;114:105–113. - PubMed
    1. Chen Y., Cao N., Lv H., Zeng K., Yuan J., Guo X., Zhao M., Tu P., Jiang Y. Anti-inflammatory and cytotoxic carbazole alkaloids from Murraya kwangsiensis. Phytochemistry. 2020;170:112186. doi: 10.1016/j.phytochem.2019.112186. - DOI - PubMed
    1. Wei R., Ma Q., Zhong G., Su Y., Yang J., Wang A., Ji T., Guo H., Wang M., Jiang P., et al. Structural characterization, hepatoprotective and antihyperlipidemic activities of alkaloid derivatives from Murraya koenigii. Phytochem. Lett. 2020;35:135–140. doi: 10.1016/j.phytol.2019.11.001. - DOI
    1. Mandal S., Nayak A., Kar M., Banerjee S.K., Das A., Upadhyay S.N., Singh R.K., Banerji A., Banerji J. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia. 2010;81:72–74. doi: 10.1016/j.fitote.2009.08.016. - DOI - PubMed

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