Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 26;15(15):3321.
doi: 10.3390/nu15153321.

Plant-Based Dietary Fibers and Polysaccharides as Modulators of Gut Microbiota in Intestinal and Lung Inflammation: Current State and Challenges

Yu Shen  1 , Mingming Song  1 , Shihao Wu  1 , Hongbo Zhao  2 , Yu Zhang  1
Affiliations
Review

Plant-Based Dietary Fibers and Polysaccharides as Modulators of Gut Microbiota in Intestinal and Lung Inflammation: Current State and Challenges

Yu Shen et al. Nutrients. .

Abstract

Recent research has underscored the significant role of gut microbiota in managing various diseases, including intestinal and lung inflammation. It is now well established that diet plays a crucial role in shaping the composition of the microbiota, leading to changes in metabolite production. Consequently, dietary interventions have emerged as promising preventive and therapeutic approaches for managing these diseases. Plant-based dietary fibers, particularly polysaccharides and oligosaccharides, have attracted attention as potential therapeutic agents for modulating gut microbiota and alleviating intestinal and lung inflammation. This comprehensive review aims to provide an in-depth overview of the current state of research in this field, emphasizing the challenges and limitations associated with the use of plant-based dietary fibers and polysaccharides in managing intestinal and lung inflammation. By shedding light on existing issues and limitations, this review seeks to stimulate further research and development in this promising area of therapeutic intervention.

Keywords: dietary fibers; gut–lung axis; intestinal inflammation; lung inflammation; phytotherapy; plant polysaccharide; prebiotics.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of plant dietary fibers and polysaccharides against gut and lung inflammation. Abbreviations: ↑, increased; ↓, decreased.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Molodecky N.A., Soon I.S., Rabi D.M., Ghali W.A., Ferris M., Chernoff G., Benchimol E.I., Panaccione R., Ghosh S., Barkema H.W., et al. Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases with Time, Based on Systematic Review. Gastroenterology. 2012;142:46–54.e42. doi: 10.1053/j.gastro.2011.10.001. - DOI - PubMed
    1. Chen L., Deng H., Cui H., Fang J., Zuo Z., Deng J., Li Y., Wang X., Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9:7204. doi: 10.18632/oncotarget.23208. - DOI - PMC - PubMed
    1. World Health Organization Chronic Obstructive Pulmonary Disease (COPD) [(accessed on 17 June 2023)]. Available online: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pul...
    1. Piovani D., Danese S., Peyrin-Biroulet L., Bonovas S. Inflammatory bowel disease: Estimates from the global burden of disease 2017 study. Aliment. Pharm. Ther. 2020;51:261–270. doi: 10.1111/apt.15542. - DOI - PubMed
    1. Barcik W., Boutin R.C.T., Sokolowska M., Finlay B.B. The Role of Lung and Gut Microbiota in the Pathology of Asthma. Immunity. 2020;52:241–255. doi: 10.1016/j.immuni.2020.01.007. - DOI - PMC - PubMed

LinkOut - more resources