Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;18(1):1-4.
doi: 10.1007/BF00253053.

Evaluation of cis-diamminedichloroplatinum(II) combined with metoclopramide or sodium thiosulfate on L1210 leukemia in vitro and in vivo

J J Catino, D M Francher, J E Schurig

Evaluation of cis-diamminedichloroplatinum(II) combined with metoclopramide or sodium thiosulfate on L1210 leukemia in vitro and in vivo

J J Catino et al. Cancer Chemother Pharmacol. 1986.

Abstract

A microtiter assay was developed to monitor cytotoxic activity of drugs alone and in combination at varying ratios on a single plate. Combinations of metoclopramide or sodium thiosulfate with cis-diamminedichloroplatinum(II) (cisplatin) were evaluated in vitro and in vivo for cisplatin cytotoxicity to murine leukemia L1210. The in vitro assay indicated that metoclopramide did not interfere with cisplatin-induced cytotoxicity and confirmed previously reported inhibition of cisplatin activity by sodium thiosulfate. The drug combinations were also evaluated in vivo for antitumor activity and the results of these studies corroborated the in vitro results.

PubMed Disclaimer

References

    1. Cancer Treat Rep. 1980 Apr-May;64(4-5):611-6 - PubMed
    1. Cancer Treat Rep. 1982 Jan;66(1):135-46 - PubMed
    1. Adv Enzyme Regul. 1984;22:27-55 - PubMed
    1. J Immunol Methods. 1983 Mar 11;58(1-2):225-37 - PubMed
    1. Cancer Treat Rev. 1979 Mar;6(1):17-39 - PubMed

MeSH terms

LinkOut - more resources