Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 14;39(4):721-727.
doi: 10.1515/reveh-2022-0104. Print 2024 Dec 17.

Research progresses on the effects of heavy metals on the circadian clock system

Qian Xue  1 , Rui Wang  1 , Ruijian Zhu-Ge  1 , Li Guo  1
Affiliations
Free article
Review

Research progresses on the effects of heavy metals on the circadian clock system

Qian Xue et al. Rev Environ Health. .
Free article

Abstract

Environmental pollution with heavy metals is widespread, thus increasing attention has been paid to their toxic effects. Recent studies have suggested that heavy metals may influence the expression of circadian clock genes. Almost all organs and tissues exhibit circadian rhythms. The normal circadian rhythm of an organism is maintained by the central and peripheral circadian clock. Thus, circadian rhythm disorders perturb normal physiological processes. Here, we review the effects of heavy metals, including manganese, copper, cadmium, and lead, on four core circadian clock genes, i.e., ARNTL, CLOCK, PER, and CRY genes.

Keywords: circadian clock gene; circadian rhythms; heavy metals.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Panda, S. The arrival of circadian medicine. Nat Rev Endocrinol 2019;15:67–9. https://doi.org/10.1038/s41574-018-0142-x . - DOI - PubMed
    1. Chen, L, Yang, G. PPARs integrate the mammalian clock and energy metabolism. PPAR Res 2014;2014:653017. https://doi.org/10.1155/2014/653017 . - DOI - PubMed - PMC
    1. Albrecht, U. Timing to perfection: the biology of central and peripheral circadian clocks. Neuron 2012;74:246–60. https://doi.org/10.1016/j.neuron.2012.04.006 . - DOI - PubMed
    1. Dibner, C, Schibler, U, Albrecht, U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 2010;72:517–49. https://doi.org/10.1146/annurev-physiol-021909-135821 . - DOI - PubMed
    1. Xie, X, Zhao, B, Huang, L, Shen, Q, Ma, L, Chen, Y, et al.. Effects of altered photoperiod on circadian clock and lipid metabolism in rats. Chronobiol Int 2017;34:1094–104. https://doi.org/10.1080/07420528.2017.1341906 . - DOI - PubMed

LinkOut - more resources