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Review
. 2023 Oct;20(6):839-877.
doi: 10.1007/s13770-023-00559-4. Epub 2023 Aug 12.

Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models

Mona M Khaled  1 , Asmaa M Ibrahium  2 , Ahmed I Abdelgalil  3 , Mohamed A El-Saied  4 , Samah H El-Bably  2
Affiliations
Review

Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models

Mona M Khaled et al. Tissue Eng Regen Med. 2023 Oct.

Abstract

Background: Peripheral nerve damage mainly resulted from traumatic or infectious causes; the main signs of a damaged nerve are the loss of sensory and/or motor functions. The injured nerve has limited regenerative capacity and is recovered by the body itself, the recovery process depends on the severity of damage to the nerve, nowadays the use of stem cells is one of the new and advanced methods for treatment of these problems.

Method: Following our review, data are collected from different databases "Google scholar, Springer, Elsevier, Egyptian Knowledge Bank, and PubMed" using different keywords such as Peripheral nerve damage, Radial Nerve, Sciatic Nerve, Animals, Nerve regeneration, and Stem cell to investigate the different methods taken in consideration for regeneration of PNI.

Result: This review contains tables illustrating all forms and types of regenerative medicine used in treatment of peripheral nerve injuries (PNI) including different types of stem cells " adipose-derived stem cells, bone marrow stem cells, Human umbilical cord stem cells, embryonic stem cells" and their effect on re-constitution and functional recovery of the damaged nerve which evaluated by physical, histological, Immuno-histochemical, biochemical evaluation, and the review illuminated the best regenerative strategies help in rapid peripheral nerve regeneration in different animal models included horse, dog, cat, sheep, monkey, pig, mice and rat.

Conclusion: Old surgical attempts such as neurorrhaphy, autogenic nerve transplantation, and Schwann cell implantation have a limited power of recovery in cases of large nerve defects. Stem cell therapy including mesenchymal stromal cells has a high potential differentiation capacity to renew and form a new nerve and also restore its function.

Keywords: And Schwann cells; Nerve regeneration; Peripheral nerve injuries; Sciatic nerve; Stem cells.

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Conflict of interest statement

There are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Summary of regenerative strategies involved in PNI
Fig. 2
Fig. 2
Animal models used in PNI
Fig. 3
Fig. 3
Numbers of trials used stem cells and other therapeutic methods
See this image and copyright information in PMC

References

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