Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023:2709:97-103.
doi: 10.1007/978-1-0716-3417-2_5.

Metalated Nucleic Acid Nanostructures

Douglas Zhang  1 , Thomas Hermann  2   3   4
Affiliations

Metalated Nucleic Acid Nanostructures

Douglas Zhang et al. Methods Mol Biol. 2023.

Abstract

Nucleic acid nanotechnology takes advantage of the self-assembling property of nucleic acids to form a variety of shapes and structures. The incorporation of metal ions into these structures introduces functionality for sensor and molecular electronic applications. Here, we describe a protocol for the incorporation of silver ions into polygonal nanoshapes that self-assemble from RNA and DNA modules.

Keywords: Metalated nanostructures; Nucleic acid nanostructures; RNA-DNA hybrid nanoshapes; Silver-mediated base pairs.

PubMed Disclaimer

References

    1. Liu D, Thélot FA, Piccirilli JA, Liao M, Yin P (2022) Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly. Nat Methods 19:576–585 - DOI - PubMed
    1. Douglas SM, Chou JJ, Shih WM (2007) DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc Natl Acad Sci 104:6644–6648 - DOI - PubMed - PMC
    1. Aksel T, Yu Z, Cheng Y, Douglas SM (2020) Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins. Nat Biotechnol 39:378–386 - DOI - PubMed - PMC
    1. Pi F et al (2017) Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression. Nat Nanotechnol 13:82–89 - DOI - PubMed - PMC
    1. Shu D, Shu Y, Haque F, Abdelmawla S, Guo P (2011) Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics. Nat Nanotechnol 6:658–667 - DOI - PubMed - PMC

Publication types

LinkOut - more resources