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Review
. 2023 Dec:80:127277.
doi: 10.1016/j.jtemb.2023.127277. Epub 2023 Aug 2.

Innovative lanthanide complexes: Shaping the future of cancer/ tumor chemotherapy

Meenakshi Patyal  1 , Kirandeep Kaur  1 , Neeraj Bala  2 , Nidhi Gupta  3 , Ashok Kumar Malik  1
Affiliations
Review

Innovative lanthanide complexes: Shaping the future of cancer/ tumor chemotherapy

Meenakshi Patyal et al. J Trace Elem Med Biol. 2023 Dec.

Abstract

Developing new therapeutic and diagnostic metals and metal complexes is a stunning example of how inorganic chemistry is rapidly becoming an essential part of modern medicine. More study of bio-coordination chemistry is needed to improve the design of compounds with fewer harmful side effects. Metal-containing drugs are widely utilized in the treatment of cancer. Platinum complexes are effective against some cancers, but new coordination compounds are being created with improved pharmacological properties and a broader spectrum of anticancer action. The coordination complexes of the 15 lanthanides or rare earth elements in the periodic table are crucial for diagnosing and treating cancer. Understanding and treating cancer requires the detection of binding lanthanide (III) ions or complexes to DNA and breaking DNA by these complexes. Current advances in lanthanide-based coordination complexes as anticancer treatments over the past five years are discussed in this study.

Keywords: Anticancer activity; Coordination chemistry; DNA; Lanthanide (III) complexes; Lanthanides.

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Conflict of interest statement

Declaration of competing interest No authors have disclosed any conflicts of interest that would have been perceived as having influenced the work presented in this paper, either financially or otherwise.

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