Variable Brugada syndrome phenotype severity in a dish: dreams meet reality

Affiliations

¹ Department of Cardiology and Angiology, Ruhr University, Bochum, Germany; Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, Germany. Electronic address: Ibrahim.el-battrawy@bergmannsheil.de.
² Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, Germany.
³ Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China. Electronic address: xiaobo.zhou@medma.uni-heidelberg.de.
⁴ Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.

Ibrahim El-Battrawy et al. EBioMedicine. 2023 Sep.

. 2023 Sep:95:104757.

doi: 10.1016/j.ebiom.2023.104757. Epub 2023 Aug 10.

¹ Department of Cardiology and Angiology, Ruhr University, Bochum, Germany; Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, Germany. Electronic address: Ibrahim.el-battrawy@bergmannsheil.de.
² Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, Germany.
³ Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China. Electronic address: xiaobo.zhou@medma.uni-heidelberg.de.
⁴ Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.

No abstract available

Conflict of interest statement

Declaration of interests The authors declare no conflict of interest.

1. Casado-Arroyo R., Berne P., Rao J.Y., et al. Long-term trends in newly diagnosed brugada syndrome: implications for risk stratification. J Am Coll Cardiol. 2016;68:614–623. doi: 10.1016/j.jacc.2016.05.073. - DOI - PubMed
1. Li Y., Lang S., Akin I., Zhou X., El-Battrawy I. Brugada syndrome: different experimental models and the role of human cardiomyocytes from induced pluripotent stem cells. J Am Heart Assoc. 2022;11 doi: 10.1161/JAHA.121.024410. - DOI - PMC - PubMed
1. Zeppenfeld K., Tfelt-Hansen J., de Riva M., et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43:3997. doi: 10.1093/eurheartj/ehac262. - DOI - PubMed
1. Chen Q., Kirsch G.E., Zhang D., et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998;392:293–296. doi: 10.1038/32675. - DOI - PubMed
1. Weiss R., Barmada M.M., Nguyen T., et al. Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3. Circulation. 2002;105:707–713. doi: 10.1161/hc0602.103618. - DOI - PubMed