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. 2023 Aug 12;21(1):538.
doi: 10.1186/s12967-023-04398-8.

Association of dietary inflammatory index with helicobacter pylori infection and mortality among US population

Yu-Jun Xiong #  1 , Lei-Lei Du #  2 , Yun-Lian Diao #  3 , Jun Wen #  4 , Xiang-Bin Meng  4 , Jun Gao  4 , Chun-Li Shao  4 , Wen-Yao Wang  4 , Xing-Yun Zhu  5 , Yi-Da Tang  6
Affiliations

Association of dietary inflammatory index with helicobacter pylori infection and mortality among US population

Yu-Jun Xiong et al. J Transl Med. .

Abstract

Background: Limited research has been conducted on the potential relationship between the dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This study aimed to investigate the association between the DII and H. pylori infection, as well as their respective impacts on all-cause mortality in a cohort of individuals with or without H. pylori infection.

Methods: Data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) were utilized for this study, with a final of 4370 participants included. Both univariable and multivariable-adjusted logistic regression analyses were employed to explore the relationship between H. pylori infection and pertinent covariates. Cox regression analysis, as well as restricted regression cubic spline analysis, were utilized to assess the association between DII and all-cause mortality among individuals with or without H. pylori infection.

Results: The findings demonstrated a positive correlation between DII scores and H. pylori infection, even after adjusting for potential confounding factors. Moreover, higher DII scores were significantly associated with an elevated risk of mortality exclusively in individuals with H. pylori infection, while no such association was observed in the uninfected population. Additional analysis using restricted cubic spline modeling revealed a positive linear relationship between DII scores as a continuous variable and the adjusted risk of all-cause mortality specifically in H. pylori-infected patients.

Conclusion: The results of this study indicated that DII was positively correlated with an increased risk of H. pylori infection and was associated with a heightened risk of all-cause mortality solely in individuals with H. pylori infection. Consequently, DII might serve as a useful tool for risk stratification in the H. pylori-infected population among U.S. adults. Further research is warranted to elucidate the underlying mechanisms and potential clinical implications of these findings.

Keywords: DII; H. pylori infection; Mortality; NHANES.

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Conflict of interest statement

The authors declared no competing interest.

Figures

Fig. 1
Fig. 1
Flow chart for inclusion and exclusion of the study population
Fig. 2
Fig. 2
Restricted cubic spline (RCS) for the association between DII and the risks of all-cause death in patients with or without H. pylori infection.
Fig. 3
Fig. 3
A Kaplan–Meier survival estimates for all-cause mortality in all participants. B Kaplan–Meier survival estimates for all-cause mortality in H. pylori positively infected participants. C Kaplan–Meier survival estimates for all-cause mortality in H. pylori negatively infected participants
See this image and copyright information in PMC

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