Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Eleanor J Molloy^{1

2

3

4

5}, Aoife Branagan^{6

7

8

9}, Tim Hurley^{6

7

9}, Fiona Quirke^{9

10

11}, Declan Devane^{10

11

12

13}, Petek E Taneri^{10

11}, Mohamed El-Dib¹⁴, Frank H Bloomfield¹⁵, Beccy Maeso¹⁶, Betsy Pilon¹⁷, Sonia L Bonifacio¹⁸, Courtney J Wusthoff¹⁹, Lina Chalak²⁰, Cynthia Bearer^{21

22}, Deirdre M Murray^{23

24}, Nadia Badawi^{25

26}, Suzann Campbell²⁷, Sarah Mulkey^{28

29

30}, Pierre Gressens³¹, Donna M Ferriero³², Linda S de Vries³³, Karen Walker^{34

35}, Sarah Kay³⁶, Geraldine Boylan^{23

24}, Chris Gale³⁷, Nicola J Robertson^{38

39}, Mary D'Alton⁴⁰, Alistair Gunn⁴¹, Karin B Nelson⁴²; Steering Group for DEFiNE (Definition of Neonatal Encephalopathy)

Affiliations

¹ Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.
² Trinity Translational Medicine Institute (TTMI), St James Hospital & Trinity Research in Childhood Centre (TRiCC), Dublin, Ireland. Eleanor.molloy@tcd.ie.
³ Neurodisability, Children's Hospital Ireland (CHI) at Tallaght, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁴ Neonatology, CHI at Crumlin, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁵ Paediatrics, The Coombe Hospital, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁶ Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
⁷ Trinity Translational Medicine Institute (TTMI), St James Hospital & Trinity Research in Childhood Centre (TRiCC), Dublin, Ireland.
⁸ Paediatrics, The Coombe Hospital, Dublin, Ireland.
⁹ Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.
¹⁰ Health Research Board-Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.
¹¹ School of Nursing and Midwifery, University of Galway, Galway, Ireland.
¹² Evidence Synthesis Ireland, University of Galway, Galway, Ireland.
¹³ Cochrane Ireland, University of Galway, Galway, Ireland.
¹⁴ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁵ Liggins Institute, University of Auckland, Auckland, New Zealand.
¹⁶ James Lind Alliance, School of Healthcare Enterprise and Innovation, University of Southampton, Southampton, UK.
¹⁷ Hope for HIE, West Bloomfield, MI, USA.
¹⁸ Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
¹⁹ Division of Child Neurology, Stanford University, Palo Alto, CA, USA.
²⁰ Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
²¹ Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
²² Case Western Reserve University School of Medicine, Cleveland, OH, USA.
²³ INFANT Research Centre, Cork, Ireland.
²⁴ Department of Pediatrics and Child Health, University College Cork, Cork, Ireland.
²⁵ Cerebral Palsy Alliance Research Institute, Specialty of Child & Adolescent Health, Sydney Medical School, Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.
²⁶ Grace Centre for Newborn Intensive Care, Sydney Children's Hospital Network, The University of Sydney, Westmead, NSW, Australia.
²⁷ Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
²⁸ Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
²⁹ Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
³⁰ Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
³¹ Université Paris Cité, NeuroDiderot, Inserm, F-75019, Paris, France.
³² Department of Pediatrics and Neurology, University of California San Francisco, Weill Institute for Neurosciences, San Francisco, CA, 94158, USA.
³³ Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
³⁴ Department of Newborn Care, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia.
³⁵ Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
³⁶ PEEPS-HIE, Manchester, UK.
³⁷ Neonatal Medicine, School of Public Health, Faculty of Medicine, Chelsea and Westminster Campus, Imperial College London, London, UK.
³⁸ Institute for Women's Health, University College London, London, UK.
³⁹ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁴⁰ Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
⁴¹ Departments of Physiology and Paediatrics, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
⁴² National Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

PMID: 37573378
DOI: 10.1038/s41390-023-02775-z

Free article

Editorial

Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Eleanor J Molloy et al. Pediatr Res. 2023 Dec.

Free article

. 2023 Dec;94(6):1860-1863.

doi: 10.1038/s41390-023-02775-z. Epub 2023 Aug 12.

Authors

Affiliations

¹ Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.
² Trinity Translational Medicine Institute (TTMI), St James Hospital & Trinity Research in Childhood Centre (TRiCC), Dublin, Ireland. Eleanor.molloy@tcd.ie.
³ Neurodisability, Children's Hospital Ireland (CHI) at Tallaght, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁴ Neonatology, CHI at Crumlin, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁵ Paediatrics, The Coombe Hospital, Dublin, Ireland. Eleanor.molloy@tcd.ie.
⁶ Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
⁷ Trinity Translational Medicine Institute (TTMI), St James Hospital & Trinity Research in Childhood Centre (TRiCC), Dublin, Ireland.
⁸ Paediatrics, The Coombe Hospital, Dublin, Ireland.
⁹ Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.
¹⁰ Health Research Board-Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.
¹¹ School of Nursing and Midwifery, University of Galway, Galway, Ireland.
¹² Evidence Synthesis Ireland, University of Galway, Galway, Ireland.
¹³ Cochrane Ireland, University of Galway, Galway, Ireland.
¹⁴ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁵ Liggins Institute, University of Auckland, Auckland, New Zealand.
¹⁶ James Lind Alliance, School of Healthcare Enterprise and Innovation, University of Southampton, Southampton, UK.
¹⁷ Hope for HIE, West Bloomfield, MI, USA.
¹⁸ Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
¹⁹ Division of Child Neurology, Stanford University, Palo Alto, CA, USA.
²⁰ Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
²¹ Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
²² Case Western Reserve University School of Medicine, Cleveland, OH, USA.
²³ INFANT Research Centre, Cork, Ireland.
²⁴ Department of Pediatrics and Child Health, University College Cork, Cork, Ireland.
²⁵ Cerebral Palsy Alliance Research Institute, Specialty of Child & Adolescent Health, Sydney Medical School, Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.
²⁶ Grace Centre for Newborn Intensive Care, Sydney Children's Hospital Network, The University of Sydney, Westmead, NSW, Australia.
²⁷ Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
²⁸ Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA.
²⁹ Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
³⁰ Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
³¹ Université Paris Cité, NeuroDiderot, Inserm, F-75019, Paris, France.
³² Department of Pediatrics and Neurology, University of California San Francisco, Weill Institute for Neurosciences, San Francisco, CA, 94158, USA.
³³ Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
³⁴ Department of Newborn Care, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia.
³⁵ Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
³⁶ PEEPS-HIE, Manchester, UK.
³⁷ Neonatal Medicine, School of Public Health, Faculty of Medicine, Chelsea and Westminster Campus, Imperial College London, London, UK.
³⁸ Institute for Women's Health, University College London, London, UK.
³⁹ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁴⁰ Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
⁴¹ Departments of Physiology and Paediatrics, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
⁴² National Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

PMID: 37573378
DOI: 10.1038/s41390-023-02775-z

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References

1. Executive Summary: Neonatal Encephalopathy and Neurologic Outcome, Second Edition. Report of the American College of Obstetricians and Gynecologists’ Task Force on Neonatal Encephalopathy. Obstet. Gynecol. 123, 896–901 (2014).
1. Dammann, O., Ferriero, D. & Gressens, P. Neonatal encephalopathy or hypoxic-ischemic encephalopathy? Appropriate terminology matters. Pediatr. Res. 70, 1–2 (2011). - DOI - PubMed
1. Aslam, S., Strickland, T. & Molloy, E. J. Neonatal encephalopathy: need for recognition of multiple etiologies for optimal management. Front. Pediatr. 7, 142 (2019). - DOI - PubMed - PMC
1. Sandoval Karamian, A. G. et al. Neonatal encephalopathy: etiologies other than hypoxic-ischemic encephalopathy. Semin. Fetal Neonatal Med. 26, 101272 (2021). - DOI - PubMed
1. McIntyre, S. et al. Neonatal encephalopathy: focus on epidemiology and underexplored aspects of etiology. Semin. Fetal Neonatal Med. 26, 101265 (2021). - DOI - PubMed

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Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Affiliations

Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Authors

Affiliations

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical