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Editorial
. 2023 Nov;19(11):2835-2836.
doi: 10.1080/15548627.2023.2247311. Epub 2023 Aug 22.

SPART links autophagy machinery and lipid droplets in motor neurons

Shree Padma Metur  1 , Daniel J Klionsky  1
Affiliations
Editorial

SPART links autophagy machinery and lipid droplets in motor neurons

Shree Padma Metur et al. Autophagy. 2023 Nov.

Abstract

Autophagy, in the form of lipophagy, is an important catabolic pathway mediating the degradation of lipid droplets and mobilization of lipids for physiological function. However, the molecular mechanism and the protein receptors that link lipid droplets/LDs to the autophagy machinery remain unknown. Here, we discuss a recent study by Chung et al. that identifies SPART as the receptor for autophagy of lipid droplets that plays an important role in the turnover of triglycerides in motor neurons.

Keywords: Lipid turnover; lysosome; neurobiology; spartin; stress.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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References

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