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Review
. 2023 Oct:82:102662.
doi: 10.1016/j.sbi.2023.102662. Epub 2023 Aug 11.

Radiation damage to biological macromolecules∗

Elspeth F Garman  1 , Martin Weik  2
Affiliations
Review

Radiation damage to biological macromolecules∗

Elspeth F Garman et al. Curr Opin Struct Biol. 2023 Oct.

Abstract

In this review, we describe recent research developments into radiation damage effects in macromolecular X-ray crystallography observed at synchrotrons and X-ray free electron lasers. Radiation damage in small molecule X-ray crystallography, small angle X-ray scattering experiments, microelectron diffraction, and single particle cryo-electron microscopy is briefly covered.

Keywords: Disulphide bond breakage; Dose; Electrons; Global damage; Microscopy; Radiation damage; Reduction; Specific structural damage; Synchrotrons; X-ray free electron lasers; X-rays.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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