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. 2023 Sep:143:105469.
doi: 10.1016/j.yrtph.2023.105469. Epub 2023 Aug 11.

Cancer weight of evidence for three lower acrylates: Conclusions and recommendations from an expert panel

C R Kirman  1 , P J Boogaard  2 , J S Bus  3 , V L Dellarco  4 , L R DePass  5 , B R Stern  6 , S M Hays  7
Affiliations
Free article

Cancer weight of evidence for three lower acrylates: Conclusions and recommendations from an expert panel

C R Kirman et al. Regul Toxicol Pharmacol. 2023 Sep.
Free article

Abstract

An international panel of experts was engaged to assess the cancer weight of evidence (WOE) for three lower acrylates: methyl acrylate, ethyl acrylate, and 2-ethylhexyl acrylate. The review was structured as a three-round, modified Delphi format, a systematic process for collecting independent and deliberative input from panel members, and it included procedural elements to reduce bias and groupthink. Based upon the available science, the panel concluded: (1) The MOA for point of contact tumors observed in rodent cancer bioassays that is best supported by available data involves increased cell replication by cytotoxicity and regenerative proliferation; (2) The WOE supports a cancer classification of "Not likely to be carcinogenic to humans" a conclusion that is more in line with an IARC classification of Group 3 rather than Group 2 B; (3) Quantitative cancer potency values based on rodent tumor data are not required for these chemicals; and (4) Human health risk assessment for these chemicals should instead rely on non-cancer, precursor endpoints observed at the point of contact (e.g., hyperplasia). The degree of consensus (consensus scores of 0.84-0.91 out of a maximum score of 1) and degree of confidence (7.7-8.7 out of a maximum score of 10) in the WOE conclusions is considered high.

Keywords: Carcinogenicity; Expert panel; Genotoxicity; Mode of action; Risk assessment; Weight of evidence.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:The project was financed by the Basic Acrylic Monomer Manufacturers (BAMM), Inc., Contract 072,522. The authors listed on the cover page certify that they have no conflict of interest to declare. Authors SMH and CRK are independent consultants and are owners of SciPinion. The paper was subjected to a review for completeness and clarity by members of BAMM and are employed by commercial companies with a financial interest in the subject matter, but were not permitted to revise opinions or conclusions.