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. 2023 Jun 1;11(8):4853-4860.
doi: 10.1002/fsn3.3462. eCollection 2023 Aug.

The antioxidant activity, preliminary phytochemical screening of Zingiber zerumbet and antimicrobial efficacy against selective endodontic bacteria

Ali A Assiry  1 , Naveed Ahmed  2 , Abdulmajeed Almuaddi  3 , Ahmed Saif  4 , Mohammed Abdulrahman Alshahrani  4 , Roshan Noor Mohamed  5 , Mohmed Isaqali Karobari  6   7
Affiliations

The antioxidant activity, preliminary phytochemical screening of Zingiber zerumbet and antimicrobial efficacy against selective endodontic bacteria

Ali A Assiry et al. Food Sci Nutr. .

Abstract

Antibiotic resistance is rising across the world. For a very long time, bitter ginger (Zingiber zerumbet) has been used as one of the most popular herbal remedies to treat a wide range of common diseases. Ginger has been shown to have antioxidant and antibacterial activity. It has various bioactive chemicals that might be utilized as an alternative treatment option for many infectious diseases. The present study aimed to examine the biochemical profile of ginger, antioxidant, and antibacterial activity against selective endodontic microbes. Antioxidant was measured using DPPH and antibacterial activity was performed using disk diffusion tests. Streptococcus mutants, Enterococcus faecalis, Staphylococcus spp., and Lactobacillus spp. were tested for antibacterial activity. Before evaluating the dried extracts, all solvents were eliminated using rotary evaporation. The obtained IC50 value revealed that ethanol extract had the greatest antioxidant activity. Concerning each bacterium, the plant extracts demonstrated considerable antibacterial activity (p = .001). Ethanol extracts showed the strongest antibacterial activity against the studied microorganisms. This study highlights that the Zingiber zerumbet (Z. zerumbet) is a strong antibacterial herb against multidrug-resistant (MDR) gram-positive bacteria. It may also be employed as a possible natural antioxidant source.

Keywords: MDR pathogens; antibacterial activity; biotechnology; dental; endodontics; ginger extract.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Antioxidant activity plant extracts by DPPH method. ZZAE, Zingiber zerumbet rhizome aqueous extract; ZZEE, Zingiber zerumbet ethanol extract.
See this image and copyright information in PMC

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