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Review
. 2023 Oct 28;11(5):1228-1238.
doi: 10.14218/JCTH.2022.00365. Epub 2023 May 11.

Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update

Kristina Bojanic  1   2   3 , Mirta Sudaric Bogojevic  4 , Sonja Vukadin  1   2 , Renata Sikora  1   3 , Gordana Ivanac  5   6 , Nikola Raguz Lucic  1   2 , Martina Smolic  1   2 , Ashraf A Tabll  7   8 , George Y Wu  9 , Robert Smolic  1   2
Affiliations
Review

Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update

Kristina Bojanic et al. J Clin Transl Hepatol. .

Abstract

Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C patients. However, with the introduction and validation of noninvasive tests (NITs) to evaluate advanced fibrosis, and the direct-acting antiviral agents for treatment of chronic hepatitis C virus (HCV), the role of NITs have become even more complex. There is now need for longitudinal monitoring and elucidation of cutoff values for prediction of liver-related complication after sustained virological response. The aim of this report is to provide a critical overview of the various NITs available for the assessment of liver fibrosis in HCV patients.

Keywords: Fibrosis; Hepatitis C virus; Magnetic resonance elastography; Noninvasive serum fibrosis markers; Shear wave elastography; Steatohepatitis; Transient elastography.

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Conflict of interest statement

GW has been an editor-in-chief of Journal of Clinical and Translational Hepatology since 2013. MS and RS have been editorial board members of Journal of Clinical and Translational Hepatology since 2013. The other authors have no conflict of interests related to this publication.

Figures

Fig. 1
Fig. 1. Schematic presentation of rule of four for LSM by SWE in viral hepatitis and NAFLD - recommendation adopted from Baveno VII consensus.
cACLD, compensated advanced chronic liver disease; CSPH, clinically significant portal hypertension; LSM, liver stiffness measurement; NAFLD, nonalcoholic fatty liver disease; SWE, shear wave elastography.
See this image and copyright information in PMC

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