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. 2023 Aug 15;12(16):e028853.
doi: 10.1161/JAHA.122.028853. Epub 2023 Aug 14.

Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation

Christine Y Bakhoum  1   2 , Samantha Madala  3 , Leonardo Lando  4   5 , Adeleh Yarmohammadi  6 , Christopher P Long  3 , Sofia Miguez  7 , Alison X Chan  6 , Maxwell Singer  7 , Andrew Jin  7 , Ben J Steren  7 , Fatemeh Adabifirouzjaei  8 , Michael H Goldbaum  6 , Anthony N DeMaria  8 , David Sarraf  9 , Mathieu F Bakhoum  7   10   11
Affiliations

Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation

Christine Y Bakhoum et al. J Am Heart Assoc. .

Abstract

Background We previously demonstrated that retinal ischemic perivascular lesions (RIPLs), which are indicative of ischemia in the middle retina, may be a biomarker of ischemic cardiovascular disease. In this study, we sought to determine the relationship between RIPLs and atrial fibrillation, a common source of cardiac emboli. Methods and Results In this case-control study, we identified individuals between the ages of 50 and 90 years who had undergone macular spectral domain optical coherence tomography imaging. Individuals with atrial fibrillation were identified, and age- and sex-matched individuals from the same pool, but without a diagnosis of atrial fibrillation, were selected as controls. Spectral domain optical coherence tomography scans were reviewed by 3 independent and masked observers for presence of RIPLs. The relationship between RIPLs and atrial fibrillation was analyzed using multivariable logistic regression models. There were 106 and 91 subjects with and without atrial fibrillation, respectively. The percentage of subjects with RIPLs was higher in the atrial fibrillation group compared with the control group (57.5% versus 37.4%; P=0.005). After adjusting for age, sex, smoking history, hypertension, diabetes, coronary artery disease, carotid stenosis, stroke, and myocardial infarction, the presence of RIPLs was significantly associated with atrial fibrillation, with an odds ratio of 1.91 (95% CI, 1.01-3.59). Conclusions RIPLs are significantly associated with atrial fibrillation, independent of underlying ischemic heart disease or cardiovascular risk factors. This association may inform the diagnostic cardiovascular workup for individuals with RIPLs incidentally detected on optical coherence tomography scan of the macula.

Keywords: atrial fibrillation; optical coherence tomography; retina; retinal ischemic perivascular lesions.

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Figures

Figure .
Figure .. Spectral domain optical coherence tomography b‐scan demonstrating a retinal ischemic perivascular lesion (RIPL) in an individual with atrial fibrillation.
The RIPL (red box) is present between 2 retinal vessels (green arrows).
See this image and copyright information in PMC

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