Back to the future: ARDS guidelines, evidence, and opinions

Luciano Gattinoni¹, Giuseppe Citerio^{2

3}, Arthur S Slutsky^{4

5}

Affiliations

¹ Department of Anesthesiology, University Medical Center Gottingen, Gottingen, Germany. gattinoniluciano@gmail.com.
² School of Medicine and Surgery, University Milano - Bicocca, Milan, Italy.
³ IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy.
⁴ Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Canada.
⁵ Keenan Research Centre, Li Ka Shing Knowledge Insitute, St. Micheal's Hospital, Unity Health Toronto, Toronto, Canada.

Editorial

Luciano Gattinoni et al. Intensive Care Med. 2023 Oct.

. 2023 Oct;49(10):1226-1228.

doi: 10.1007/s00134-023-07183-9. Epub 2023 Aug 14.

Luciano Gattinoni¹, Giuseppe Citerio^{2

3}, Arthur S Slutsky^{4

5}

¹ Department of Anesthesiology, University Medical Center Gottingen, Gottingen, Germany. gattinoniluciano@gmail.com.
² School of Medicine and Surgery, University Milano - Bicocca, Milan, Italy.
³ IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy.
⁴ Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Canada.
⁵ Keenan Research Centre, Li Ka Shing Knowledge Insitute, St. Micheal's Hospital, Unity Health Toronto, Toronto, Canada.

No abstract available

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ARDS Ventilation, The Man Behind the Evolution.
Prayag S. Prayag S. Indian J Crit Care Med. 2025 Jan;29(1):12-13. doi: 10.5005/jp-journals-10071-24887. Epub 2024 Dec 30. Indian J Crit Care Med. 2025. PMID: 39802240 Free PMC article.
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Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS.
Li K, Zhou Z, Liu F, Huang Z, Chen X, Zhou F. Li K, et al. Sci Rep. 2025 Apr 30;15(1):15207. doi: 10.1038/s41598-025-00028-z. Sci Rep. 2025. PMID: 40307322 Free PMC article.
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Stroh JN, Sottile PD, Wang Y, Smith BJ, Bennett TD, Moss M, Albers DJ. Stroh JN, et al. medRxiv [Preprint]. 2025 Jan 16:2023.12.14.23299978. doi: 10.1101/2023.12.14.23299978. medRxiv. 2025. PMID: 38168309 Free PMC article. Preprint.

1. Grasselli G et al (2023) ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med. https://doi.org/10.1007/S00134-023-07050-7 - DOI - PubMed - PMC
1. Gattinoni L et al (2001) Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 345(8):568–573. https://doi.org/10.1056/NEJMOA010043 - DOI - PubMed
1. Fernandez R et al (2008) Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med 34(8):1487–1491. https://doi.org/10.1007/S00134-008-1119-3 - DOI - PubMed
1. Mancebo J et al (2006) A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 173(11):1233–1239. https://doi.org/10.1164/RCCM.200503-353OC - DOI - PubMed
1. Taccone P et al (2009) Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 302(18):1977–1984. https://doi.org/10.1001/JAMA.2009.1614 - DOI - PubMed