BEST3-Mediated MEKK2/3 Activation: A Novel Therapeutic Target in Aortopathies
- PMID: 37579014
- PMCID: PMC10430773
- DOI: 10.1161/CIRCULATIONAHA.123.065946
BEST3-Mediated MEKK2/3 Activation: A Novel Therapeutic Target in Aortopathies
Keywords: Editorials; aneurysm; angiotensins; aorta; dissection; myocytes, smooth muscle; vascular diseases.
Conflict of interest statement
Comment on
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Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection.Circulation. 2023 Aug 15;148(7):589-606. doi: 10.1161/CIRCULATIONAHA.122.063029. Epub 2023 May 19. Circulation. 2023. PMID: 37203562
References
-
- Zhang TT, Lei QQ, He J, Guan X, Zhang X, Huang Y, Zhou ZY, Fan RX, Wang T, Li CX, et al. Bestrophin3 deficiency in vascular smooth muscle cells activates MEKK2/3-MAPK signaling to trigger spontaneous aortic dissection. Circulation. 2023. - PubMed
-
- Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347:1260419. - PubMed
-
- Jiang L, Liu Y, Ma MM, Tang YB, Zhou JG, Guan YY. Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells. Apoptosis. 2013;18:556–565. - PubMed
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