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. 2023 Sep;29(9):1925-1928.
doi: 10.3201/eid2909.230417. Epub 2023 Aug 14.

Evaluating SARS-CoV-2 Saliva and Dried Blood Spot Surveillance Strategies in a Congregate Population

Liana R Andronescu, Stephanie A Richard, Eric D Laing, Nora Pisanic, Si'Ana A Coggins, Magdielis Gregory Rivera, Kate Kruczynski, Adam K Saperstein, Jitendrakumar Modi, Jamie A Fraser, Saira Shaikh, Christopher C Broder, Timothy H Burgess, Christopher D Heaney, Simon D Pollett, Eugene Millar, Christian L Coles, Mark P Simons

Evaluating SARS-CoV-2 Saliva and Dried Blood Spot Surveillance Strategies in a Congregate Population

Liana R Andronescu et al. Emerg Infect Dis. 2023 Sep.

Abstract

The optimal approach to COVID-19 surveillance in congregate populations remains unclear. Our study at the US Naval Academy in Annapolis, Maryland, USA, assessed the concordance of antibody prevalence in longitudinally collected dried blood spots and saliva in a setting of frequent PCR-based testing. Our findings highlight the utility of salivary-based surveillance.

Keywords: COVID-19; SARS-CoV-2; congregate population; coronavirus disease; dried blood spot; respiratory infections; saliva; severe acute respiratory syndrome coronavirus 2; strategies; surveillance; vaccine-preventable diseases; viruses; zoonoses.

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Figures

Figure 1
Figure 1
Quantitative comparison of spike IgG in saliva and dried blood spots among 79 study participants, US Naval Academy, Annapolis, Maryland, USA, December 2020–May 2021.
Figure 2
Figure 2
Quantitative comparison of nucleocapsid IgG in saliva and dried blood spots among 79 study participants, US Naval Academy, Annapolis, Maryland, USA, December 2020–May 2021. N, nucleocapsid.
See this image and copyright information in PMC

References

    1. Diepstra K, Bullington BW, Premkumar L, Shook-Sa BE, Jones C, Pettifor A. SARS-CoV-2 seroprevalence: demographic and behavioral factors associated with seropositivity among college students in a university setting. J Adolesc Health. 2022;71:559–69. 10.1016/j.jadohealth.2022.06.015 - DOI - PMC - PubMed
    1. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, et al. A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect. 2021;54:12–6. 10.1016/j.jmii.2020.05.001 - DOI - PMC - PubMed
    1. Ralli M, Morrone A, Arcangeli A, Ercoli L. Asymptomatic patients as a source of transmission of COVID-19 in homeless shelters. Int J Infect Dis. 2021;103:243–5. 10.1016/j.ijid.2020.12.031 - DOI - PMC - PubMed
    1. Sah P, Fitzpatrick MC, Zimmer CF, Abdollahi E, Juden-Kelly L, Moghadas SM, et al. Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis. Proc Natl Acad Sci U S A. 2021;118:e2109229118. 10.1073/pnas.2109229118 - DOI - PMC - PubMed
    1. Kimball A, Hatfield KM, Arons M, James A, Taylor J, Spicer K, et al.; Public Health – Seattle & King County; CDC COVID-19 Investigation Team. Public Health–Seattle & King County; CDC COVID-19 Investigation Team. Asymptomatic and presymptomatic SARS-CoV-2 infections in residents of a long-term care skilled nursing facility—King County, Washington, March 2020. MMWR Morb Mortal Wkly Rep. 2020;69:377–81. 10.15585/mmwr.mm6913e1 - DOI - PMC - PubMed

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