Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;25(9):1254-1264.
doi: 10.1038/s41556-023-01197-7. Epub 2023 Aug 14.

Balancing lysosome abundance in health and disease

Anders P Mutvei  1   2 , Michal J Nagiec  3 , John Blenis  4
Affiliations
Review

Balancing lysosome abundance in health and disease

Anders P Mutvei et al. Nat Cell Biol. 2023 Sep.

Abstract

Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.

PubMed Disclaimer

References

    1. Liu, G. Y. & Sabatini, D. M. mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. 21, 183–203 (2020). - PubMed - PMC - DOI
    1. Lawrence, R. E. & Zoncu, R. The lysosome as a cellular centre for signalling, metabolism and quality control. Nat. Cell Biol. 21, 133–142 (2019). - PubMed - DOI
    1. Kim, J., Kundu, M., Viollet, B. & Guan, K.-L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132–141 (2011). - PubMed - PMC - DOI
    1. Yim, W. W.-Y. & Mizushima, N. Lysosome biology in autophagy. Cell Discov. 6, 6 (2020). - PubMed - PMC - DOI
    1. Kim, J. & Guan, K.-L. mTOR as a central hub of nutrient signalling and cell growth. Nat. Cell Biol. 21, 63–71 (2019). - PubMed - DOI

Publication types

LinkOut - more resources