Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;46(9):1249-1256.
doi: 10.1007/s00270-023-03523-w. Epub 2023 Aug 14.

Cryoablation for Bone and Soft Tissue Lesions in Pediatric Patients: Complications and Preventive Measures

Kumar Kempegowda Shashi  1 , Mohamed M Shahin  2 , Patrick Johnston  2 , Raja Shaikh  3
Affiliations

Cryoablation for Bone and Soft Tissue Lesions in Pediatric Patients: Complications and Preventive Measures

Kumar Kempegowda Shashi et al. Cardiovasc Intervent Radiol. 2023 Sep.

Abstract

Purpose: To evaluate complications associated with cryoablation in a pediatric population and review preventive measures to mitigate these complications.

Material and methods: Retrospective study including all the image guided cryoablations performed on pediatric population. Immediate and delayed complications were analyzed, and we identified the different protective measures used and the clinical outcomes from follow-up. Point estimates for the percentage of complications were calculated by maximum likelihood, and 95% confidence intervals for the true percentages were calculated using the Clopper-Pearson exact method.

Results: Eighty-seven ablations were performed on 68 patients (age range of 2-18 years, mean 12.4 years) for non-neoplastic (70%) and neoplastic (30%) lesions. The percentage of ablations resulting in complications was 18% (95% confidence interval (CI) 11% to 28%). Of these, 5% (95% CI 1% to 11%) were grade 3 complications, and 14% (95% CI 7% to 23%) were grade 2 complications. Thermal protection was performed in 27.6% of ablations (n = 24). The mean clinical follow-up duration was 348 days.

Conclusion: Cryoablation in pediatric patients is relatively safe, with a major complication rate per ablation of 5%. Thermal protective measures can be considered to mitigate these complications.

Keywords: Complications; Cryoablation; Pediatric; Pediatric tumors; Soft tissue tumors; Vascular malformations.

PubMed Disclaimer

References

    1. Shaikh R. Percutaneous image-guided cryoablation in vascular anomalies. Semin Intervent Radiol. 2017;34(3):280–7. - DOI - PubMed - PMC
    1. Auloge P, Cazzato RL, Rousseau C, et al. Complications of percutaneous bone tumor cryoablation: a 10-year experience. Radiology. 2019;291(2):521–8. - DOI - PubMed
    1. Cazzato RL, Garnon J, Ramamurthy N, et al. Percutaneous image-guided cryoablation: current applications and results in the oncologic field. Med Oncol. 2016;33(12):140. - DOI - PubMed
    1. Miyazaki M, Saito K, Yanagawa T, Chikuda H, Tsushima Y. Phase I clinical trial of percutaneous cryoablation for osteoid osteoma. Jpn J Radiol. 2018;36(11):669–75. - DOI - PubMed
    1. Serrano E, Zarco F, Gill AE, et al. Percutaneous cryoablation of chondroblastoma and osteoblastoma in pediatric patients. Insights Imaging. 2021;12(1):106. - DOI - PubMed - PMC

LinkOut - more resources