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. 2023 Nov;83(7):653-664.
doi: 10.1002/jdn.10293. Epub 2023 Aug 14.

Stunting and wasting in neurological Wilson disease: Role of copper, zinc, and insulin-like growth factor-I

Vijay Kumar  1 , Jayantee Kalita  2 , Usha Kant Misra  3   4 , Vasudev Parashar  5
Affiliations

Stunting and wasting in neurological Wilson disease: Role of copper, zinc, and insulin-like growth factor-I

Vijay Kumar et al. Int J Dev Neurosci. 2023 Nov.

Abstract

Objectives: Copper (Cu) and zinc (Zn) are important trace elements for the growth and development of children. In Wilson disease (WD), impaired Cu metabolism may affect growth. This study was conducted to evaluate the height and weight of children with neurological WD and correlate these with serum Cu, Zn, and insulin-like growth factor-I (IGF-I).

Methods: This prospective cohort study was conducted in a tertiary care teaching institute. Children with neurologic WD were included. The height, weight, and body-mass index of each child were measured and categorized according to the revised national growth chart. Serum Cu, Zn, calcium, alkaline phosphatase, albumin, thyroid-stimulating hormone, and urinary-Cu were measured. Serum IGF-1 was measured by enzyme-linked immunosorbent assay. The relationship between height and weight with trace elements and IGF was analyzed using parametric or non-parametric tests.

Results: There were 52 children (5-18 years) with neurologic WD. Thirty-six (69.2%) children had normal height, 12 (23.1%) were tall, and 4 (7.7%) were stunted. Forty-six (88.5%) children had normal weight and six (11.5%) children were underweight. IGF-1 correlated with height, weight, duration of treatment, and serum Zn level. About 15.4% of children had stunting and/or wasting, which was associated with low levels of serum IGF-I, Zn, and calcium.

Conclusions: Stunting and/or wasting occurs in 15.4% of children with neurologic WD and is associated with reduced serum IGF-I, Zn, and calcium concentration. Adjunctive Zn and calcium treatment may help in achieving normal growth.

Keywords: IGF-I; Wilson disease; calcium; copper; growth; zinc.

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References

REFERENCES

    1. Arvanitidou, V., Voskaki, I., Tripsianis, G., Athanasopoulou, H., Tsalkidis, A., Filippidis, S., Schulpis, K., & Androulakis, I. (2007). Serum copper and zinc concentrations in healthy children aged 3-14 years in Greece. Biological Trace Element Research, 115(1), 1-12. https://doi.org/10.1385/BTER:115:1:1
    1. Bost, M., Houdart, S., Oberli, M., Kalonji, E., Huneau, J. F., & Margaritis, I. (2016). Dietary copper and human health: Current evidence and unresolved issues. Journal of Trace Elements in Medicine and Biology, 35, 107-115. https://doi.org/10.1016/j.jtemb.2016.02.006
    1. Chen, J., Jiang, Y., Shi, H., Peng, Y., Fan, X., & Li, C. (2020). The molecular mechanisms of copper metabolism and its roles in human diseases. Pflügers Archiv, 472(10), 1415-1429. https://doi.org/10.1007/s00424-020-02412-2
    1. Czlonkowska, A., Litwin, T., Dusek, P., Ferenci, P., Lutsenko, S., Medici, V., Rybakowski, J. K., Weiss, K. H., & Schilsky, M. L. (2018). Wilson disease. Nature Reviews. Disease Primers, 4(1), 21. https://doi.org/10.1038/s41572-018-0018-3
    1. Dauth, N., Mucke, V. T., Mucke, M. M., Lange, C. M., Welker, M., Zeuzem, S., & Badenhoop, K. (2021). Hypopituitarism in Wilson's disease resolved after copper-chelating therapy. Endocrinology, Diabetes & Metabolism Case Reports, 2021(1). https://doi.org/10.1530/EDM-20-0086

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