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Editorial
. 2023 Sep 5;122(17):3544-3548.
doi: 10.1016/j.bpj.2023.08.002. Epub 2023 Aug 15.

Sarcomere mechanics in the double-actin-overlap zone

Robert Rockenfeller  1 , Michael Günther  2 , Scott L Hooper  3
Affiliations
Editorial

Sarcomere mechanics in the double-actin-overlap zone

Robert Rockenfeller et al. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Sarcomere forces generated by various XBs. Actin filaments, red; myosin filaments, blue; myosin heads, cyan; bare zone, green. Left neighbor of sarcomere of interest shown in transparent colors. Mid column: schematic sketches of rXBs, fXBs, sXBs, and lrXBs formed by a single myosin head (protruding always from the left half-sarcomere's myosin (part) of the right sarcomere). Other myosin heads of the same sarcomere not shown for clarity. Force directions on actin and myosin filaments indicated by arrows of corresponding color. Right column: element (elastic springs plus motor) circuitry diagrams of the action of a single XB force ΔF0 (motor). Note XB force is negative (eccentric) for sXB and positive (concentric) for the other XB types. The initial lengths (ℓi=ℓ0;i=1,2,3,4) of the four half-sarcomeres in the circuitry diagrams add to give the total length of the two sarcomeres: ℓtotal=4·ℓ0=ℓ1+ℓ2+ℓ3+ℓ4; the isometric condition is ℓtotal=constant (Δℓtotal=0). The four half-sarcomere forces Fi=F0+K·Δℓi equalize in isometric equilibrium, where F0 is the preload. To see this figure in color, go online.
See this image and copyright information in PMC

Comment on

References

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    1. Rode C., Tomalka A., et al. Siebert T. Structurally motivated models to explain the muscle’s force-length relationship. Biophys. J. 2023 (Comment to the Editor) - PMC - PubMed
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    1. Ramsey R.W., Street S.F. The isometric length-tension diagram of isolated skeletal muscle fibers of the frog. J. Cell. Comp. Physiol. 1940;15:11–34.
    1. Tomalka A., Heim M., et al. Siebert T. Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc. J. R. Soc. Interface. 2022;19 - PMC - PubMed

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