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. 2023 Aug;44(8):788-794.
doi: 10.15537/smj.2023.44.8.20230084.

Antenatal steroid as an independent risk factor for vitamin K2 deficiency in newborns: A Chinese single-center, retrospective study

Ling Liu  1 , Chao-Hong Chen  1 , Shi-Wen Rong  1 , Shao-Zhu Lin  1 , Na-Li Cai  1 , Dang Ao  1
Affiliations

Antenatal steroid as an independent risk factor for vitamin K2 deficiency in newborns: A Chinese single-center, retrospective study

Ling Liu et al. Saudi Med J. 2023 Aug.

Abstract

Objectives: To identified vitamin K2 deficiency rate and risk factors among newborns in China and assess the importance of high-risk maternal intakes of vitamin K2.

Methods: This retrospective study was performed at the Neonatology Department, the Affiliated Hospital of Guangdong Medical University, China. Routinely collected mother-neonate hospitalization data from July 2020 to January 2021 were analyzed. In total, data from 200 neonates who had completed vitamin K2 tests were utilized to assess the prevalence of vitamin K2 deficiency and identify the potential risk factors. According to the vitamin K2 level, the neonates were divided into 2 groups: cases (vitamin K2 deficiency) and controls (no vitamin K2 deficiency). The potential risk factors for vitamin K2 deficiency were evaluated by univariate and multivariate logistic regression.

Results: The vitamin K2 level in 24 of the 200 neonates was undetectable (<0.05 ng/mL). The prevalence of low serum vitamin K2 (<0.1 ng/ml) was 33%. Study subjects with antenatal corticosteroids use had an approximately 5-fold greater risk of developing vitamin K2 deficiency. In the univariate analyses, small-for-gestational-age (SGA), caesarean section, maternal gestational diabetes and premature rupture of the membranes were risk factors for vitamin K2 deficiency. In the multivariate logistic regression analysis, high antenatal corticosteroids use, cesarean section, and SGA were independently associated with vitamin K2 deficiency.

Conclusion: The present study demonstrated that antenatal corticosteroids use is independently associated with vitamin K2 deficiency. This finding highlights the importance of routine vitamin K2 supplementation in late-stage pregnant women and neonates in China.

Keywords: China; cesarean section; corticosteroids; premature infants; vitamin K2.

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Figures

Figure 1
Figure 1
- Comparison of vitamin K2 level in case and control group.
Figure 2
Figure 2
- Adjusted odds ratios for calculating risk factors for vitamin K2 deficiency using multivariate logistic regression analysis. *P<0.05, **P<0.01.
See this image and copyright information in PMC

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