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. 2023 Aug 15;24(1):651.
doi: 10.1186/s12891-023-06770-7.

The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)

P Savvari  1 , I Skiadas  2 , S A Papadakis  3 , V Psychogios  4 , O D Argyropoulou  5 , A P Pastroudis  6 , G A Skarpas  7 , A Tsoutsanis  8 , A Garofalakis  9 , G Katsifis  10 , D Boumpas  11 , D Menegas  2
Affiliations

The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)

P Savvari et al. BMC Musculoskelet Disord. .

Abstract

Background: Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients.

Objectives: To evaluate the impact of moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality of life.

Methods: A non-interventional, cross-sectional, epidemiological study of patients with moderate/severe OA, recruited in a single visit from 9 expert sites in Athens, Greece. Assessments were based on commonly used outcome scales: the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the EuroQol-5-Dimensions 3-levels questionnaire (EQ-5D-3L).

Results: One hundred sixty-four patients were included in the analysis. Most of the patients were females (78.7%), with a mean age of 70.5 ± 10.2 years. Comorbidities were reported by 87.2% of patients with hypertension being the most frequently reported (53.7%), followed by dyslipidemia (31.1%), obesity (24.4%) and diabetes mellitus (23.2%). Paracetamol was the most common treatment (96%), followed by NSAIDs (75%), opioids (50%) and locally applied medications (42.7%). Both hip and knee OA patients showed substantial deterioration in health-related quality of life (QoL) and health status as reflected by the HOOS/KOOS (Function in sport and recreation was the most impaired subscale, followed by Hip- or Knee-related QoL). The mean EQ-5D-3L index score was 0.396 ± 0.319 and the mean EQ-VAS score was 52.1 ± 1.9. When compared indirectly to the local population norms our OA population had worse QoL indices.

Conclusion: Our findings suggest the functional disability and impaired QoL of Greek patients with moderate/severe hip/knee OA under treatment emphasizing the need for novel treatments that will reduce the burden of the disease.

Keywords: Health Related Quality of Life (HRQoL); Hip osteoarthritis; Joint diseases; Knee osteoarthritis; Musculoskeletal diseases.

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Conflict of interest statement

P.Savvari, I.Skiadas and D.Menegas are currently Pfizer employees. Stamatios A Papadakis, Vasilis Psychogios, Ourania D. Argyropoulou, Alexandros P. Pastroudis, George A. Skarpas, Athanasios Tsoutsanis, Andreas Garofalakis, Gikas Katsifis, Dimitrios Boumpas have no competing interest.

Figures

Fig. 1
Fig. 1
HOOS and KOOS profile. C.I. = Confidence Interval; HOOS = Hip dysfunction and Osteoarthritis Outcome score; KOOS = Knee injury and Osteoarthritis Outcome score
Fig. 2
Fig. 2
EQ-VAS frequency distribution (histogram). EQ VAS = EuroQol Visual Analogue Scale
See this image and copyright information in PMC

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