Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Sep 15;42(9):1022-3.
doi: 10.1007/BF01940715.

Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes

K Yoshioka, H Nishimura

Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes

K Yoshioka et al. Experientia. .

Abstract

The effect of lipophilic cations such as triphenylmethylphosphonium, tetraphenylphosphonium and tetraphenylarsonium in addition to dibenzyldimethylammonium on thiamine transport in isolated rat hepatocytes was studied. Lipophilic cations at the concentration 10 microM almost completely inhibited thiamine uptake. Kinetic studies showed that these compounds were competitive inhibitors with a very high affinity. These results suggest that lipophilic cations in addition to quaternary ammonium compounds also share a common binding site for thiamine in isolated rat hepatocytes.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Biochem J. 1961 Aug;80:324-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2352-6 - PubMed
    1. Biochim Biophys Acta. 1984 Nov 21;778(1):201-9 - PubMed
    1. Am J Physiol. 1976 Apr;230(4):1101-7 - PubMed
    1. Biochim Biophys Acta. 1983 Jul 13;732(1):308-11 - PubMed