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Review
. 2024 Feb;38(1):33-41.
doi: 10.1111/fcp.12947. Epub 2023 Aug 16.

Can cannabidiol have an analgesic effect?

Bartłomiej Kulesza  1 , Marek Mazurek  2 , Jacek Kurzepa  1
Affiliations
Review

Can cannabidiol have an analgesic effect?

Bartłomiej Kulesza et al. Fundam Clin Pharmacol. 2024 Feb.

Abstract

Background: Cannabis, more commonly known as marijuana or hemp, has been used for centuries to treat various conditions. Cannabis contains two main components cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD, unlike THC, is devoid of psychoactive effects and is well tolerated by the human body but has no direct effect on the receptors of the endocannabid system, despite the lack of action on the receptors of the endocannabid system.

Objectives and methods: We have prepared a literature review based on the latest available literature regarding the analgesic effects of CBD. CBD has a wide range of effects on the human body. In this study, we will present the potential mechanisms responsible for the analgesic effect of CBD. To the best of our knowledge, this is the first review to explore the analgesic mechanisms of CBD.

Results and conclusion: The analgesic effect of CBD is complex and still being researched. CBD models the perception of pain by acting on G protein-coupled receptors. Another group of receptors that CBD acts on are serotonergic receptors. The effect of CBD on an enzyme of potential importance in the production of inflammatory factors such as cyclooxygenases and lipoxygenases has also been confirmed. The presented potential mechanisms of CBD's analgesic effect are currently being extensively studied.

Keywords: CBD; analgesic effect; analgesic mechanism; cannabidiol; cannabis.

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References

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