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Review
. 2023 Dec;38(6):1253-1262.
doi: 10.1002/ncp.11064. Epub 2023 Aug 16.

Safety in parenteral nutrition compounding

Andrew Mays  1   2 , Phil Ayers  2   3 , Jessica Monczka  4 , Mary Petrea Cober  5   6
Affiliations
Review

Safety in parenteral nutrition compounding

Andrew Mays et al. Nutr Clin Pract. 2023 Dec.

Abstract

Parenteral nutrition (PN) compounding is a complex process that requires knowledge and training to ensure the safety and efficacy of this form of nutrition support therapy. Unfortunately, errors and lack of adherence to safe PN compounding recommendations and sterile compounding requirements have resulted in patient injury and death. These lapses in the safe provision of PN have been the result of various factors, including a lack of understanding of PN compatibility, stability, and sterility requirements, as well as drug product shortages and order entry errors. This review will describe the current challenges with the education and training regarding PN compounding, compatibility and stability of PN admixtures, simultaneous administration of nonnutrient medications with PN admixtures, and specific challenges with special populations such as neonates, pediatrics, and those receiving home care.

Keywords: compounding; parenteral nutrition; parenteral nutrition formulas; safety.

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References

REFERENCES

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