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. 2023 Oct 1;158(10):1106-1108.
doi: 10.1001/jamasurg.2023.2774.

Normal Graft Function After Pig-to-Human Kidney Xenotransplant

Jayme E Locke  1 , Vineeta Kumar  1 , Douglas Anderson  1 , Paige M Porrett  1
Affiliations

Normal Graft Function After Pig-to-Human Kidney Xenotransplant

Jayme E Locke et al. JAMA Surg. .
No abstract available

Plain language summary

This case series examines the ability of a pig-to-human xenograft to provide life-sustaining kidney function.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Locke reported receiving personal fees from Sanofi and a patent pending outside the submitted work. Dr Kumar reported receiving honoraria from Medscape and the University of Alabama at Birmingham, National Kidney Foundation, Rogosin Institute, American Society of Nephrology, American Society of Transplantation, AFLD, and Advance Renal Education Program outside the submitted work. Dr Anderson reported receiving grants from Hansa Biopharma outside the submitted work.

Figures

Figure 1.
Figure 1.. Kidney Function Over Time After 10-Gene–Edited Pig-to-Human Xenotransplant
Xenograft-associated declining serum creatinine and increasing creatinine clearance in the absence of native kidneys and dialysis were consistent with life-sustaining kidney function after pig-to-human kidney xenotransplant. POD indicates postoperative day.
Figure 2.
Figure 2.. Kidney Histopathology After 10-Gene–Edited (10GE) Pig-to-Human Xenotransplant
Original magnification ×40. POD indicates postoperative day.
See this image and copyright information in PMC

References

    1. Porrett PM, Orandi BJ, Kumar V, et al. . First clinical-grade porcine kidney xenotransplant using a human decedent model. Am J Transplant. 2022;22(4):1037-1053. doi:10.1111/ajt.16930 - DOI - PubMed
    1. Montgomery RA, Stern JM, Lonze BE, et al. . Results of two cases of pig-to-human kidney xenotransplantation. N Engl J Med. 2022;386(20):1889-1898. doi:10.1056/NEJMoa2120238 - DOI - PubMed