Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Sep;44(9):665-667.
doi: 10.1016/j.it.2023.07.007. Epub 2023 Aug 15.

To eat or not to eat: type 2 immunity controls food avoidance behavior

Albana L Kodra  1 , Daniel Mucida  2
Affiliations
Comment

To eat or not to eat: type 2 immunity controls food avoidance behavior

Albana L Kodra et al. Trends Immunol. 2023 Sep.

Abstract

Growing evidence suggests that food allergies are regulated by neuroimmune interactions. However, the underlying molecular mechanisms remain unclear. Plum et al. and Florsheim et al. identify IgE-mediated mast cell activation, leukotrienes, and growth differentiating factor 15 (GDF15) as key regulators of the avoidance response to food allergens in mice.

Keywords: allergy; food allergy; immunology; neuroimmune.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interests.

Comment on

  • Immune sensing of food allergens promotes avoidance behaviour.
    Florsheim EB, Bachtel ND, Cullen JL, Lima BGC, Godazgar M, Carvalho F, Chatain CP, Zimmer MR, Zhang C, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Florsheim EB, et al. Nature. 2023 Aug;620(7974):643-650. doi: 10.1038/s41586-023-06362-4. Epub 2023 Jul 12. Nature. 2023. PMID: 37437602 Free PMC article.
  • Mast cells link immune sensing to antigen-avoidance behaviour.
    Plum T, Binzberger R, Thiele R, Shang F, Postrach D, Fung C, Fortea M, Stakenborg N, Wang Z, Tappe-Theodor A, Poth T, MacLaren DAA, Boeckxstaens G, Kuner R, Pitzer C, Monyer H, Xin C, Bonventre JV, Tanaka S, Voehringer D, Vanden Berghe P, Strid J, Feyerabend TB, Rodewald HR. Plum T, et al. Nature. 2023 Aug;620(7974):634-642. doi: 10.1038/s41586-023-06188-0. Epub 2023 Jul 12. Nature. 2023. PMID: 37438525 Free PMC article.

Publication types

LinkOut - more resources