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Case Reports
. 2023 Oct 17;85(10):1047-1051.
doi: 10.1292/jvms.23-0243. Epub 2023 Aug 16.

Effect of tolvaptan on hyponatremia in a dog with syndrome of inappropriate secretion of antidiuretic hormone

Hiroka Yamamoto  1 , Kyoga Kimura  2 , Hiro Horikirizono  3 , Yojiro Tamura  4 , Satoshi Kambayashi  2 , Kenji Baba  2 , Masaru Okuda  2 , Takuya Mizuno  1 , Masaya Igase  1
Affiliations
Case Reports

Effect of tolvaptan on hyponatremia in a dog with syndrome of inappropriate secretion of antidiuretic hormone

Hiroka Yamamoto et al. J Vet Med Sci. .

Abstract

A 1-year-old spayed female Miniature Schnauzer had chronic hyponatremia, accompanied by polyuria and polydipsia. Blood tests and urinalysis revealed severe hyponatremia, low plasma osmolality with euvolemia, and increased sodium excretion in urine. Hypothyroidism and hypoadrenocorticism were ruled out as causes. These findings led to the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Magnetic resonance imaging (MRI) showed dilation of the lateral ventricles, indicating severe hydrocephalus. Tolvaptan, a vasopressin V2 receptor antagonist commonly used in human SIADH, was administered along with water restriction. This treatment resulted in a consistent increase in plasma sodium levels without any adverse effects. This case report represents the first documented evidence of the therapeutic efficacy of tolvaptan in treating SIADH in a dog.

Keywords: congenital hydrocephalus; dog; syndrome of inappropriate secretion of antidiuretic hormone; tolvaptan.

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Conflict of interest statement

The authors have no conflict of interest to disclose.

Figures

Fig. 1.
Fig. 1.
Transverse and sagital T2-weighted magnetic resonance imaging of the brain at the temporomandibular joint level indicated the dilation of lateral ventricles.
Fig. 2.
Fig. 2.
Change in plasma sodium (Na) concentration (mEq/L) from day 0 (first day of admission to our department) to the last day of follow-up.
See this image and copyright information in PMC

References

    1. Barrot AC, Bédard A, Dunn M. 2017. Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. Can Vet J 58: 713–715. - PMC - PubMed
    1. Biel M, Kramer M, Forterre F, Jurina K, Lautersack O, Failing K, Schmidt MJ. 2013. Outcome of ventriculoperitoneal shunt implantation for treatment of congenital internal hydrocephalus in dogs and cats: 36 cases (2001–2009). J Am Vet Med Assoc 242: 948–958. doi: 10.2460/javma.242.7.948 - DOI - PubMed
    1. Bowles KD, Brainard BM, Coleman KD. 2015. Syndrome of inappropriate antidiuretic hormone in a bulldog with aspiration pneumonia. J Vet Intern Med 29: 972–976. doi: 10.1111/jvim.12577 - DOI - PMC - PubMed
    1. Brofman PJ, Knostman KAB, DiBartola SP. 2003. Granulomatous amebic meningoencephalitis causing the syndrome of inappropriate secretion of antidiuretic hormone in a dog. J Vet Intern Med 17: 230–234. doi: 10.1111/j.1939-1676.2003.tb02439.x - DOI - PubMed
    1. Dugger DT, Epstein SE, Hopper K, Mellema MS. 2014. A comparison of the clinical utility of several published formulae for estimated osmolality of canine serum. J Vet Emerg Crit Care (San Antonio) 24: 188–193. doi: 10.1111/vec.12153 - DOI - PubMed

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