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Comment
. 2023 Aug 16;14(1):4912.
doi: 10.1038/s41467-023-40510-8.

Reply to: The pitfalls of interpreting hyperintense FLAIR signal as lymph outside the human brain

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Comment

Reply to: The pitfalls of interpreting hyperintense FLAIR signal as lymph outside the human brain

Mehmet Sait Albayram et al. Nat Commun. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Visualization of the diaphragma sella.
A Sagittal FLAIR images show the putative ventral dural lymphatic elements in the diaphragma sella (double arrowhead; (adapted from Figure 4c of Albayram et al., Nat. Commun. 13, 203 (2022)). B Moreover, we can identify a subtle linear pattern, most likely the diaphragma sella (yellow arrowhead) in Ringstad et al. Figure 1c, just under their arrow, as presented below (with contrast adjustment); (adapted from Fig. 1c at Rinstad et al., Nat. Commun. submitted).

Comment on

References

    1. Albayram MS, et al. Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes. Nat. Commun. 2022;13:203. doi: 10.1038/s41467-021-27887-0. - DOI - PMC - PubMed
    1. Ringstad, G. & Eide, P. K. All that glitters outside brain at MRI-FLAIR is not lymph. Nat. Commun.10.1038/s41467-023-40508-2 (2023).
    1. Mezey É, et al. An immunohistochemical study of lymphatic elements in the human brain. Proc. Natl Acad. Sci. USA. 2021;118:e2002574118. doi: 10.1073/pnas.2002574118. - DOI - PMC - PubMed
    1. Aspelund A, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 2015;212:991–999. doi: 10.1084/jem.20142290. - DOI - PMC - PubMed
    1. Ringstad G, Eide PK. Cerebrospinal fluid tracer efflux to parasagittal dura in humans. Nat. Commun. 2020;11:354. doi: 10.1038/s41467-019-14195-x. - DOI - PMC - PubMed