Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Jul 31;12(7):1883-1886.
doi: 10.21037/tcr-23-541. Epub 2023 Jul 6.

Non-targeted biopsies in hereditary diffuse gastric cancer: Necessary, but not enough

Affiliations
Editorial

Non-targeted biopsies in hereditary diffuse gastric cancer: Necessary, but not enough

Kole H Buckley et al. Transl Cancer Res. .
No abstract available

Keywords: CDH1; E-cadherin; Surveillance; hereditary diffuse gastric cancer (HDGC).

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-541/coif). BWK reports that he receives grants from DeGregorio Family Foundation and American Gastroenterological Association. The other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Proposed criteria for assessment of pale lesions.

Comment on

References

    1. Hansford S, Kaurah P, Li-Chang H, et al. Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. JAMA Oncol 2015;1:23-32. 10.1001/jamaoncol.2014.168 - DOI - PubMed
    1. Majewski IJ, Kluijt I, Cats A, et al. An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol 2013;229:621-9. 10.1002/path.4152 - DOI - PubMed
    1. Lobo S, Benusiglio PR, Coulet F, et al. Cancer predisposition and germline CTNNA1 variants. Eur J Med Genet 2021;64:104316. 10.1016/j.ejmg.2021.104316 - DOI - PubMed
    1. Guilford P, Hopkins J, Harraway J, et al. E-cadherin germline mutations in familial gastric cancer. Nature 1998;392:402-5. 10.1038/32918 - DOI - PubMed
    1. Clark DF, Michalski ST, Tondon R, et al. Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer. Genet Med 2020;22:840-6. 10.1038/s41436-020-0753-1 - DOI - PMC - PubMed