. 2022 Aug 26;3(4):375-389.

doi: 10.1007/s43657-022-00068-9. eCollection 2023 Aug.

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer's Disease

Mei Tian^{1

2

3}, Chuantao Zuo^{1

4}, Ali Cahid Civelek⁵, Ignasi Carrio⁶, Yasuyoshi Watanabe⁷, Keon Wook Kang⁸, Koji Murakami⁹, Valentina Garibotto¹⁰, John O Prior¹¹, Henryk Barthel¹², Yihui Guan¹, Jiaying Lu¹, Rui Zhou³, Chentao Jin³, Shuang Wu³, Xiaohui Zhang³, Yan Zhong³, Hong Zhang^{3

13

14

15}; Molecular Imaging-Based Precision Medicine Task Group of A3 (China-Japan-Korea) Foresight Program

Affiliations

¹ PET Center, Huashan Hospital, Fudan University, Shanghai, 200235 China.
² Human Phenome Institute, Fudan University, Shanghai, 201203 China.
³ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009 China.
⁴ National Center for Neurological Disorders and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040 China.
⁵ Department of Radiology and Radiological Science, Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins Medicine, Baltimore, 21287 USA.
⁶ Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, 08025 Spain.
⁷ Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047 Japan.
⁸ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080 Korea.
⁹ Department of Radiology, Juntendo University Hospital, Tokyo, 113-8431 Japan.
¹⁰ Diagnostic Department, University Hospitals of Geneva and NIMTlab, University of Geneva, Geneva, 1205 Switzerland.
¹¹ Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, 1011 Switzerland.
¹² Department of Nuclear Medicine, Leipzig University Medical Center, Leipzig, 04103 Germany.
¹³ Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009 China.
¹⁴ The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, 310007 China.
¹⁵ Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310007 China.

PMID: 37589025
PMCID: PMC10425321
DOI: 10.1007/s43657-022-00068-9

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer's Disease

Mei Tian et al. Phenomics. 2022.

. 2022 Aug 26;3(4):375-389.

doi: 10.1007/s43657-022-00068-9. eCollection 2023 Aug.

Authors

Affiliations

¹ PET Center, Huashan Hospital, Fudan University, Shanghai, 200235 China.
² Human Phenome Institute, Fudan University, Shanghai, 201203 China.
³ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009 China.
⁴ National Center for Neurological Disorders and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040 China.
⁵ Department of Radiology and Radiological Science, Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins Medicine, Baltimore, 21287 USA.
⁶ Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, 08025 Spain.
⁷ Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047 Japan.
⁸ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080 Korea.
⁹ Department of Radiology, Juntendo University Hospital, Tokyo, 113-8431 Japan.
¹⁰ Diagnostic Department, University Hospitals of Geneva and NIMTlab, University of Geneva, Geneva, 1205 Switzerland.
¹¹ Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, 1011 Switzerland.
¹² Department of Nuclear Medicine, Leipzig University Medical Center, Leipzig, 04103 Germany.
¹³ Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009 China.
¹⁴ The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, 310007 China.
¹⁵ Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310007 China.

PMID: 37589025
PMCID: PMC10425321
DOI: 10.1007/s43657-022-00068-9

Abstract

Alzheimer's disease (AD) is the main cause of dementia, with its diagnosis and management remaining challenging. Amyloid positron emission tomography (PET) has become increasingly important in medical practice for patients with AD. To integrate and update previous guidelines in the field, a task group of experts of several disciplines from multiple countries was assembled, and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals, focusing on clinical scenarios, patient preparation, administered activities, as well as image acquisition, processing, interpretation and reporting. In addition, expert opinions, practices, and protocols of prominent research institutions performing research on amyloid PET of dementia are integrated. With the increasing availability of amyloid PET imaging, a complete and standard pipeline for the entire examination process is essential for clinical practice. This international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

Keywords: Alzheimer’s disease; Amyloid; Brain imaging; Expert consensus; Positron emission tomography (PET).

PubMed Disclaimer

Conflict of interest statement

Conflicts of InterestThe authors declare that they have no conflict of interest.

Figures

**Fig. 1**
The flowchart of the recommended examination procedures in performing amyloid PET scanning and reporting

**Fig. 2**
The visual assessment algorithm of amyloid PET images includes color scale of displayed images (a), observation sequence (b), assessment of image quality (c), negative-image signs (d) and positive-image signs (e)

See this image and copyright information in PMC

Cited by

Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study.
Li Y, Wang L, Zhong J, Xu H, Han Y; Alzheimer's Disease Neuroimaging Initiative; Zuo C, Jiang J. Li Y, et al. Alzheimers Dement. 2024 Sep;20(9):6542-6555. doi: 10.1002/alz.14149. Epub 2024 Aug 6. Alzheimers Dement. 2024. PMID: 39107995 Free PMC article.
Diagnostic performance of artificial intelligence-assisted PET imaging for Parkinson's disease: a systematic review and meta-analysis.
Wang J, Xue L, Jiang J, Liu F, Wu P, Lu J, Zhang H, Bao W, Xu Q, Ju Z, Chen L, Jiao F, Lin H, Ge J, Zuo C, Tian M. Wang J, et al. NPJ Digit Med. 2024 Jan 22;7(1):17. doi: 10.1038/s41746-024-01012-z. NPJ Digit Med. 2024. PMID: 38253738 Free PMC article.
Improved interpretation of ¹⁸F-florzolotau PET in progressive supranuclear palsy using a normalization-free deep-learning classifier.
Lu J, Clement C, Hong J, Wang M, Li X, Cavinato L, Yen TC, Jiao F, Wu P, Wu J, Ge J, Sun Y, Brendel M, Lopes L, Rominger A, Wang J, Liu F, Zuo C, Guan Y, Zhao Q, Shi K; Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Lu J, et al. iScience. 2023 Jul 20;26(8):107426. doi: 10.1016/j.isci.2023.107426. eCollection 2023 Aug 18. iScience. 2023. PMID: 37564702 Free PMC article.
Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson's Disease.
Niu J, Zhong Y, Jin C, Cen P, Wang J, Cui C, Xue L, Cui X, Tian M, Zhang H. Niu J, et al. Neurosci Bull. 2024 Jun;40(6):743-758. doi: 10.1007/s12264-024-01188-0. Epub 2024 Mar 14. Neurosci Bull. 2024. PMID: 38483697 Free PMC article. Review.
Medical image Generative Pre-Trained Transformer (MI-GPT): future direction for precision medicine.
Zhang X, Zhong Y, Jin C, Hu D, Tian M, Zhang H. Zhang X, et al. Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):332-335. doi: 10.1007/s00259-023-06450-7. Eur J Nucl Med Mol Imaging. 2024. PMID: 37803245 No abstract available.

See all "Cited by" articles

References

1. Akamatsu G, Ikari Y, Ohnishi A, Matsumoto K, Nishida H, Yamamoto Y, et al. Voxel-based statistical analysis and quantification of amyloid PET in the Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) multi-center study. EJNMMI Res. 2019;9(1):91. doi: 10.1186/s13550-019-0561-2. - DOI - PMC - PubMed
1. Arnaoutoglou NA, O'Brien JT, Underwood BR. Dementia with Lewy bodies - from scientific knowledge to clinical insights. Nat Rev Neurol. 2019;15(2):103–112. doi: 10.1038/s41582-018-0107-7. - DOI - PubMed
1. Battle MR, Pillay LC, Lowe VJ, Knopman D, Kemp B, Rowe CC, et al. Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods. EJNMMI Res. 2018;8(1):107. doi: 10.1186/s13550-018-0456-7. - DOI - PMC - PubMed
1. Beach TG, Thal DR, Zanette M, Smith A, Buckley C. Detection of Striatal amyloid plaques with [18F]flutemetamol: validation with postmortem histopathology. J Alzheimers Dis. 2016;52(3):863–873. doi: 10.3233/JAD-150732. - DOI - PubMed
1. Bourgeat P, Doré V, Doecke J, Ames D, Masters CL, Rowe CC, et al. Non-negative matrix factorisation improves centiloid robustness in longitudinal studies. NeuroImage. 2021;226:117593. doi: 10.1016/j.neuroimage.2020.117593. - DOI - PMC - PubMed

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer's Disease

Affiliations

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer's Disease

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources