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. 2023 Dec;71(12):3947-3950.
doi: 10.1111/jgs.18557. Epub 2023 Aug 17.

Neutralization and binding antibody response to second bivalent COVID-19 vaccination in nursing home residents

Oladayo A Oyebanji  1 , Yasin Abul  2   3   4 , Brigid M Wilson  5 , Jurgen Bosch  6 , Elise M Didion  5 , Alexandra N Paxitzis  1 , Nicholas Sundheimer  1 , Vaishnavi Ragavapuram  6 , Dennis Wilk  1 , Debbie Keresztesy  1 , Htin Aung  1 , Yi Cao  7 , Christopher L King  6 , Alejandro B Balazs  7 , Elizabeth M White  2 , Stefan Gravenstein  3   4   8 , David H Canaday  1   5
Affiliations

Neutralization and binding antibody response to second bivalent COVID-19 vaccination in nursing home residents

Oladayo A Oyebanji et al. J Am Geriatr Soc. 2023 Dec.
No abstract available

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Conflict of interest statement

Conflict of Interest

Figures

Figure 1.
Figure 1.. Neutralization titers for Wuhan and Omicron BA.5 in nursing home residents up to the second bivalent dose.
Geometric mean titers and their 95% confidence intervals were calculated for each time point, strain, and assay. Two pairs of time points, post-1st bivalent vs. post-2nd bivalent and 3–6 month post-1st bivalent vs. post-2nd bivalent were compared for each titer using paired t-tests on the log-transformed titer values to compare the geometric mean fold change to 1. Blue dots represent pNT50 for serum from those without prior infection, red dots from those with prior infection. Significant fold-change differences indicated above, * corresponding to p < 0.05, ** to p < 0.01, and *** to p < 0.001. P-values were unadjusted. Other statistical comparisons are not shown. The M3–6 month post-1st BV draw was obtained with a median of 180 days after vaccination (range 97–189 days). All analyses were performed using R Version 4.2.2. Abbreviations. MV Monovalent, BV Bivalent.
Figure 2.
Figure 2.. Anti-spike antibody titers for Wuhan and Omicron BA.5 in nursing home residents up to the second bivalent dose.
Geometric mean titers and their 95% confidence intervals were calculated for each time point, strain, and assay. Two pairs of time points, post-1st bivalent vs. post-2nd bivalent and 3–6 month post-1st bivalent vs. post-2nd bivalent were compared for each titer using paired t-tests on the log-transformed titer values to compare the geometric mean fold change to 1. Blue dots represent anti-S titers for serum from those without prior infection, red dots from those with prior infection. Significant fold-change differences indicated above, ** corresponding to p < 0.01. P-values were unadjusted. Other statistical comparisons are not shown. The M3–6 month post-1st bivalent draw has obtained a median of the day 180 days after vaccination (range 97–189 days). All analyses were performed using R Version 4.2.2. Abbreviations. MV Monovalent, BV Bivalent
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References

    1. Centers for Medicare & Medicaid Services: COVID-19 Nursing Home Data (online). Available at https://data.cms.gov/covid-19/covid-19-nursing-home-data. Accessed July 7, 2023
    1. Canaday DH, Oyebanji OA, White EM, et al. SARS-CoV-2 Antibody Responses to the Ancestral SARS-CoV-2 Strain and Omicron BA.1 and BA.4/BA.5 Variants in Nursing Home Residents After Receipt of Bivalent COVID-19 Vaccine - Ohio and Rhode Island, September-November 2022. MMWR-Morbid Mortal W Rep. 2023. Jan 27;72(4):100–106. doi: 10.15585/mmwr.mm7204a4. PMID: 36701254; PMCID: PMC9925133. - DOI - PMC - PubMed
    1. Gravenstein S, DeVone F, Oyebanji OA, et al. Durability of immunity and clinical protection in nursing home residents following bivalent SARS-CoV-2 vaccination. medRxiv [Preprint]. 2023. Apr 25. doi: 10.1101/2023.04.25.23289050. PMID: 37163130. - DOI - PMC - PubMed
    1. Canaday DH, Oyebanji OA, White E, et al. COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents. EBioMedicine. 2022;80:104066. - PMC - PubMed
    1. Nugent C, Abul Y, White EM, et al. Second monovalent SARS-CoV-2 mRNA booster restores Omicron-specific neutralizing activity in both nursing home residents and health care workers. Vaccine. 2023. May 22;41(22):3403–3409. doi: 10.1016/j.vaccine.2023.04.034. Epub 2023 Apr 24. PMID: 37117056; PMCID: PMC10123357. - DOI - PMC - PubMed

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